Publications by authors named "L de Koning"
Background: Exposing blood specimens to air reduces plasma total carbon dioxide (TCO). We evaluated the degree of TCO reduction attributed to open collection of neonatal blood in BD microtainers® (microtainers), microtainer transport duration and delayed testing of open plasma aliquots.
Methods: Venous blood was aliquoted into open microtainers in a 3x4 factorial design to simulate combined effects of blood volume (0.
The microtubule-disrupting agent 2-methoxyestradiol (2-ME) displays anti-tumor and anti-angiogenic properties, but its clinical development is halted due to poor pharmacokinetics. We therefore designed two 2-ME analogs in silico-an ESE-15-one and an ESE-16 one-with improved pharmacological properties. We investigated the effects of these compounds on the cytoskeleton in vitro, and their anti-angiogenic and anti-metastatic properties in ovo.
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- Congenital cytomegalovirus (cCMV) is a common viral infection in newborns, with maternal CMV serology tests typically starting with IgM and IgG antibody assessment.
- In a study of five perinatal cases, cCMV was diagnosed in fetuses despite negative maternal IgM results during the second trimester, highlighting the limitations of this test.
- The findings suggest that a negative maternal CMV IgM does not rule out cCMV, making prenatal CMV testing important along with autopsy and placental evaluations for unexplained fetal issues.
Background Information: Arpin, an Arp2/3 inhibitory protein, inhibits lamellipodial protrusions and cell migration. Arpin expression is lost in tumor cells of several cancer types.
Results: Here we analyzed expression levels of Arpin and various markers using Reverse Phase Protein Array (RPPA) in human mammary carcinomas.