Publications by authors named "L de Gabory"
Background: Clinical trials have demonstrated the effectiveness of biologics in treating chronic rhinosinusitis with nasal polyps (CRSwNP). However, real-world evidence regarding patient outcomes and predictors of clinical response remains limited.
Methodology: In this multicentric 18-month follow-up study, 326 adult patients who initiated biologic therapy for severe uncontrolled CRSwNP were included.
Article Synopsis
- Salivary gland Secretory Carcinoma (SC) is a rare tumor first described in 2010; a study analyzed 108 cases from the REFCOR database to evaluate diagnosis, treatment, and survival rates up to July 2021.
- MRI was found to be ineffective for diagnosing malignancy, and while 79% of patients received a diagnosis after two histological readings, 21% needed molecular testing for confirmation.
- Results showed high survival rates, with 91.4% overall survival and 89% recurrence-free survival at five years, suggesting a generally positive prognosis for SC patients.*
Interpretation of surgical mapping is essential for postoperative radiotherapy planning. Operative and pathological reports lack comprehensive information on margins quality and tissue block mapping. Standardizing reports is essential to reduce uncertainties, aiming for less morbid poRT.
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- Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common condition affecting 2% of people, typically treated with corticosteroids and saline rinses, with surgery as an option for those who don't respond to medication.
- In France, two biologic treatments are available for severe cases that don’t improve after existing therapies or surgery, and a new study will evaluate the effectiveness and safety of these biologics in real-life settings.
- The BIOlogics in severe nasal POlyposis SurvEy (BIOPES) is a national, multicenter study aimed at understanding the impact of biologics on CRSwNP patients and gathering various clinical data to inform future treatments.
Background: Among all studies describing COVID-19 clinical features during the first wave of the pandemic, only a few retrospective studies have assessed the correlation between olfac-tory dysfunction (OD) and the evolution of disease severity. The main aim was to assess whether OD is a predictive factor of COVID-19 severity based on the patient's medical management (outpa-tient care, standard hospital admission, and ICU admission).
Methods: A national, prospective, mul-ticenter cohort study was conducted in 20 public hospitals and a public center for COVID-19 screen-ing.