Publications by authors named "L de Bus"
Purpose: Mortality and morbidity of patients with bloodstream infection (BSI) remain high despite advances in diagnostic methods and efforts to speed up reporting. This study investigated the impact of reporting rapid Minimum Inhibitory Concentration (MIC)-results in Gram negative BSIs with the ASTar system (Q-linea, Uppsala, Sweden) on the adaptation of empirically started antimicrobial therapy. We performed a real-world study during which antimicrobial susceptibility testing (AST) results were instantly reported to the treating physician in an established multidisciplinary antimicrobial stewardship setting.
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- The D-PRISM study investigated global practices for diagnosing and treating pneumonia in ICU settings, focusing on community-acquired, hospital-acquired, and ventilator-associated pneumonia across different countries.
- A survey gathered responses from 1,296 ICU clinicians across 72 countries, revealing varied diagnostic processes and a lack of standardized microbiological testing, particularly in lower-income regions.
- Findings indicated that the typical antibiotic treatment duration was 5-7 days, with shorter durations linked to effective antimicrobial stewardship programs in higher-income countries.
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- A study investigated the effects of carbapenems as initial antibiotics on mortality rates in critically ill patients with bacterial infections, utilizing data from 268 patients across 31 Japanese ICUs.
- Results showed no significant difference in 28-day mortality between patients treated with carbapenems and those who were not (18% vs 16%).
- However, a longer duration of carbapenem use was associated with an increased risk of detecting multidrug-resistant pathogens.
Background: Hospital-acquired bloodstream infections are common in the intensive care unit (ICU) and have a high mortality rate. Patients with cirrhosis are especially susceptible to infections, yet there is a knowledge gap in the epidemiological distinctions in hospital-acquired bloodstream infections between cirrhotic and non-cirrhotic patients in the ICU. It has been suggested that cirrhotic patients, present a trend towards more gram-positive infections, and especially enterococcal infections.
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