Performance of two combination disk methods as confirmation for ESBL and AmpC presence in clinical Enterobacterales isolates.

Purpose: Guidelines recommend the use of a combination disk method (CDM) including cefepime and clavulanic acid as a confirmation method for ESBL detection. However, an alternative CDM containing cloxacillin (combining ceftazidime and cefotaxime with clavulanic acid and/or cloxacillin), is not only able to confirm ESBL presence, but also to provide information about AmpC production. We aim to show non-inferiority of the cloxacillin-CDM compared to the cefepime-CDM.

Modulating the developing gut microbiota with 2'-fucosyllactose and pooled human milk oligosaccharides.

Background: Synthetic human milk oligosaccharides (HMOs) are used to supplement infant formula despite limited understanding of their impact on the post-weaned developing gut microbiota. Here, we assess the influence of 0.5 g/L 2-fucosyllactose (2'FL) and 4.

A Pilot Study Exploring the Relationship Between Milk Composition and Microbial Capacity in Breastfed Infants.

Background: Maternal obesity may contribute to childhood obesity in a myriad of ways, including through alterations of the infant gut microbiome. For example, maternal obesity may contribute both directly by introducing a dysbiotic microbiome to the infant and indirectly through the altered composition of human milk that fuels the infant gut microbiome. In particular, indigestible human milk oligosaccharides (HMOs) are known to shape the composition of the infant gut microbiome.

Autologous minced cartilage implantation in osteochondral lesions of the talus-does fibrin make the difference?

Introduction: Implantation of minced cartilage is a one-step-procedure that leads to satisfactory results in osteochondral defects.

Material And Methods: A retrospective review was performed on a consecutive cohort of patients that received minced cartilage with fibrin (MCF), minced cartilage with membrane and fibrin (MCMF) and minced cartilage with the "AutoCart"-procedure (MCAC) between January 2019 and December 2023. Radiological outcome parameters were evaluated via Magnet-Resonance-Tomography (MRI) within one year using Ankle-Osteoarthritis-Scoring-System (AOSS).

2'-Fucosyllactose inhibits human norovirus replication in human intestinal enteroids.

Unlabelled: Human noroviruses (HuNoVs) are the leading cause of acute gastroenteritis worldwide. Currently, there are no targeted antivirals for the treatment of HuNoV infection. Histo-blood group antigens (HBGAs) on the intestinal epithelium are cellular attachment factors for HuNoVs; molecules that block the binding of HuNoVs to HBGAs thus have the potential to be developed as antivirals.