Publications by authors named "L Zurnadzhy"
Deletion of the long q arm of chromosome 22 (22qDEL) is the most frequently identified recurrent somatic copy number alteration (SCNA) observed in papillary thyroid carcinoma (PTC). Since its role in PTC is not fully understood, we conducted a pooled analysis of genomic characteristics and clinical correlates in 1094 primary tumors from four published PTC genomic studies. The majority of PTC with 22qDEL exhibited arm-level loss of heterozygosity (86%); nearly all PTC with 22qDEL had losses in 22q12 and 13, which together constitute 70% of the q arm.
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- Childhood exposure to radioactive iodine from the Chornobyl accident increases the risk of papillary thyroid carcinoma (PTC), particularly in younger individuals.
- A study of 428 PTC cases found that cervical lymph node metastases (cLNM) were more common in PTC with certain genetic fusions compared to mutations, and this frequency varied significantly by specific gene types.
- Molecular profiling of the cLNM showed strong genetic concordance with primary PTCs and identified 17 differentially expressed genes, pointing to potential biological mechanisms in PTC metastasis that require further investigation.
Introduction: The radioiodine-refractory (RAI-R) recurrent papillary thyroid carcinomas (PTCs) are more frequent in elderly patients and have an unfavorable prognosis. Data on the prevalence and characteristics of RAI-R recurrent PTCs in patients of young and middle age with or without a history of radiation exposure in childhood are poorly described. The aim of the current study was: i) to determine the frequency of RAI-R recurrent PTCs among donors of the Chornobyl Tissue Bank (CTB) and analyze the clinicopathological features of primary tumors (PTs), primary metastases (PMTSs), recurrent metastases (RMTSs) and risk factors for RMTS, and ii) to determine the immune checkpoint status (ICS) of the RAI-R recurrent PTCs and to assess the factors associated with ICS positivity.
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- The increase in thyroid cancer globally, especially papillary thyroid microcarcinomas (MPTCs), raises questions on how certain factors like radiation exposure impact tumor characteristics and prognosis after the Chornobyl disaster.
- A study involving 465 patients from highly contaminated areas revealed that longer latency periods correlated with a lower probability of causation from radiation and larger tumor sizes.
- Despite changes in tumor characteristics, such as increased invasiveness and the frequency of certain mutations, latency, probability of causation, and tumor size did not affect disease recurrence rates after treatment.
The high degree of similarity in histopathological and clinical characteristics between radiogenic and sporadic papillary thyroid microcarcinomas in young patients.
Front Endocrinol (Lausanne)
September 2022
The potential overtreatment of patients with papillary thyroid microcarcinoma (MPTC) has been an important clinical problem in endocrine oncology over the past decade. At the same time, current clinical guidelines tend to consider prior radiation exposure as a contraindication to less extensive surgery, even for low-risk thyroid carcinomas, which primarily include microcarcinomas. This study aims to determine whether there are differences in the behavior of MPTC of two etiological forms (radiogenic and sporadic), including invasive properties, clinical data, and recurrence in patients aged up to 30 years.
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