Publications by authors named "L Zirpel"
Overactive bladder patients suffer from a frequent, uncontrollable urge to urinate, which can lead to a poor quality of life. We aim to improve open-loop sacral neuromodulation therapy by developing a conditional stimulation paradigm using neural recordings from dorsal root ganglia (DRG) as sensory feedback. Experiments were performed in 5 anesthetized felines.
View Article and Find Full Text PDFFeasibility of Real-Time Conditional Sacral Neuromodulation Using Wireless Bladder Pressure Sensor.
IEEE Trans Neural Syst Rehabil Eng
October 2021
Article Synopsis
- Continuous sacral neuromodulation (SNM) effectively treats overactive bladder by reducing leakage and increasing storage capacity, while conditional SNM adapts stimulation based on bladder conditions.
- A study using a wireless bladder pressure sensor and the Medtronic Summit RC+S system tested four conditional SNM methods over five days on four female sheep, aiming to prove the effectiveness of a closed-loop system.
- Results showed that the neurostimulator successfully executed stimulation commands rapidly, and while there was weak correlation with catheter-based pressure measurements, the system could still accurately trigger SNM, indicating potential for personalized treatment in future human applications.
Article Synopsis
- The study aims to assess how different sub-sensory amplitude settings of sacral neuromodulation therapy affect overactive bladder symptoms in individuals with urinary urge incontinence.
- Participants were divided into three groups based on amplitude settings and filled out various questionnaires to track changes in urinary symptoms and quality of life over 12 weeks.
- Results showed significant reductions in urinary incontinence episodes for all groups, with improvements in quality of life and overall bladder condition, highlighting potential benefits of personalized therapy settings for better patient comfort and device longevity.
Aim: Sacral neuromodulation (SNM) is a widely adopted treatment for overactive bladder, non-obstructive urinary retention and faecal incontinence. In the majority, it provides sustained clinical benefit. However, it is recognized that, even for these patients, stimulation parameters (such as amplitude, electrode configuration, frequency and pulse width) may vary at both initial device programming and at reprogramming, the latter often being required to optimize effectiveness.
View Article and Find Full Text PDFImpact of electrical stimulation of the stomach on gastric distension-induced emesis in the musk shrew.
Neurogastroenterol Motil
August 2016
Background: Gastric electrical stimulation (GES) is implicated as a potential therapy for difficult-to-treat nausea and vomiting; however, there is a lack of insight into the mechanisms responsible for these effects. This study tested the relationship between acute GES and emesis in musk shrews, an established emetic model system.
Methods: Urethane-anesthetized shrews were used to record emetic responses (monitoring intra-tracheal pressure and esophageal contractions), respiration rate, heart rate variability, blood pressure, and gastrointestinal electromyograms.