Publications by authors named "L Zgaga"
The determination of endogenous steroids in hair and fur: A systematic review of methodologies.
J Steroid Biochem Mol Biol
February 2025
Background: Endogenous steroid hormone assessment is essential for clinical practice. These hormones are typically measured in blood. More recently, measurement of steroids in hair samples has been gaining in popularity, so we have reviewed the methodologies used for this to-date.
View Article and Find Full Text PDFBackground And Aims: Randomized clinical trials (RCTs) assessing semaglutide reported reductions of systolic blood pressure (SBP) in trial populations with baseline blood pressure in the normotensive range. This study aimed to determine whether this SBP reduction is greater in hypertensive groups.
Methods: Individual patient data (IPD) from three RCTs examining the effect of semaglutide 2.
Article Synopsis
- Immunosuppressive treatment for rheumatic diseases helps maintain remission but raises infection risk and diminishes response to SARS-CoV-2 vaccination.
- The study evaluated immune responses to SARS-CoV-2 in two patient groups: one during acute infection and one post-vaccination, comparing results among those exposed to rituximab, other immunosuppressive treatments, and non-immunosuppressed individuals.
- Results showed that while non-immunosuppressed patients had stronger T cell responses during infection, those on immunosuppression had reduced activation, with rituximab-treated patients showing preserved T cell responses but poor antibody production post-vaccination.
Background & Aims: Many determinants of vitamin D status have been well-described, yet supplementation guidelines largely follow a one-size-for-all model and deficiency remains common. We hypothesised that accounting accurately for ultraviolet-B (UVB) radiation and considering interactions could advance understanding of vitamin D status.
Methods: Asian, Black, and White participants from the UK Biobank cohort were included (N = 438,978).
Article Synopsis
- The study aimed to explore how levels of circulating 25-hydroxyvitamin D (25-OHD) relate to survival outcomes in colorectal cancer (CRC) patients.
- Analyses were conducted using data from the Study of Colorectal Cancer in Scotland (SOCCS) and the UK Biobank, where patients with lower 25-OHD levels had significantly poorer cancer-specific and overall survival compared to those with higher levels.
- However, the research did not find a causal relationship between 25-OHD levels and survival outcomes, indicating that while lower levels correlate with worse survival, they may not directly cause it.