Publications by authors named "L Zeise"
Background: Current US federal action levels for domoic acid (DA) in seafood are based on acute toxicity observed in exposed adult humans. Life course considerations have not been incorporated. The potential for developmental neurotoxicity (DNT) at permissible DA levels has previously been noted, but not methodically assessed.
View Article and Find Full Text PDFMetabolism-disrupting agents (MDAs) are chemical, infectious or physical agents that increase the risk of metabolic disorders. Examples include pharmaceuticals, such as antidepressants, and environmental agents, such as bisphenol A. Various types of studies can provide evidence to identify MDAs, yet a systematic method is needed to integrate these data to help to identify such hazards.
View Article and Find Full Text PDFArticle Synopsis
- The global production of industrial chemicals is rising, leading to health risks and disproportionate impacts on low-wealth and communities of color.
- Multiple health organizations are urging improved regulations to protect against harmful exposures.
- A set of five consensus recommendations aims to enhance EPA policies, emphasizing accountability for chemical producers, recognizing potential hazards even without data, better protecting at-risk populations, reevaluating assumptions about "safe" exposure levels, and addressing conflicts of interest in risk assessments.
Human health risk assessment currently uses the reference dose or reference concentration (RfD, RfC) approach to describe the level of exposure to chemical hazards without appreciable risk for non-cancer health effects in people. However, this "bright line" approach assumes that there is minimal risk below the RfD/RfC with some undefined level of increased risk at exposures above the RfD/RfC and has limited utility for decision-making. Rather than this dichotomous approach, non-cancer risk assessment can benefit from incorporating probabilistic methods to estimate the amount of risk across a wide range of exposures and define a risk-specific dose.
View Article and Find Full Text PDFBackground: Despite their large numbers and widespread use, very little is known about the extent to which per- and polyfluoroalkyl substances (PFAS) can cross the placenta and expose the developing fetus.
Objective: The aim of our study is to develop a computational approach that can be used to evaluate the of extend to which small molecules, and in particular PFAS, can cross to cross the placenta and partition to cord blood.
Methods: We collected experimental values of the concentration ratio between cord and maternal blood (R) for 260 chemical compounds and calculated their physicochemical descriptors using the cheminformatics package Mordred.