Cortex-wide characterization of decision-making neural dynamics during spatial navigation.

Decision-making during freely moving behaviors involves complex interactions among many cortical and subcortical regions. However, the spatiotemporal coordination across regions to generate a decision is less understood. Using a head-mounted widefield microscope, cortex-wide calcium dynamics were recorded in mice expressing GCaMP7f as they navigated an 8-maze using two paradigms.

Early and widespread engagement of the cerebellum during hippocampal epileptiform activity Format: Brief Communication.

Despite research illustrating the cerebellum may be a critical circuit element in the epilepsies, remarkably little is known about cerebellar engagement during seizures. We therefore implemented a novel method for repeated imaging of the cerebellum in awake, chronically epileptic animals. We found widespread changes in cerebellar calcium signals during behavioral seizures during hippocampal seizures that remained electrographic only, arguing against cerebellar modulation simply reflecting motor components.