Publications by authors named "L Zareba"
Background: Asthma is associated with a prothrombotic state. Plasma factor VIIa-antithrombin complex concentrations (FVIIa-AT) indirectly reflect the interaction of tissue factor (TF) with FVII. Since TF is a key initiator of coagulation in vivo, we hypothesized that FVIIa-AT are higher in asthma.
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- Systemic lupus erythematosus (SLE) is an autoimmune disease that leads to tissue damage caused by the activation of immune cells and the production of autoantibodies.
- A study of 35 SLE patients found that increased disease activity was associated with specific B cell subsets and inflammatory markers, including plasmaplasts and complement levels.
- The findings suggest a need for personalized management strategies to identify patients at higher risk of experiencing flare-ups.
Article Synopsis
- Lupus nephritis (LN) is a kidney inflammation linked to systemic lupus erythematosus (SLE), and the study investigated the clinical and laboratory differences between LN and non-LN SLE patients at a university hospital in Kraków, Poland.
- Out of 921 SLE patients analyzed, 331 had LN, which presented at a younger age (29 vs. 37 years) and a higher male proportion compared to non-LN patients, who also had a higher occurrence of certain antibodies like anti-cardiolipin IgM.
- LN patients showed more severe symptoms, required more immunosuppressive treatment, and had specific risk factors for experiencing multiple LN flares, underscoring the need for
Objective: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a variable clinical manifestation, potentially leading to death. Importantly, patients with SLE have an increased risk of neoplastic disorders. Thus, this study aimed to comprehensively evaluate the clinical and laboratory characteristics of patients with SLE and with or without malignancy.
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- - Hyperbaric oxygen (HBO) therapy involves inhaling pure oxygen in a pressurized chamber and may influence circulating small extracellular vesicles (sEVs), which are important for health and disease.
- - A pilot study examined the effects of HBO therapy on sEV levels in 80 patients with necrotizing soft-tissue infections, sudden hearing loss, and aseptic bone necrosis, finding a significant increase in sEVs, particularly in the hearing loss group.
- - The elevated sEV levels suggest HBO therapy may reduce inflammation and oxidative stress, indicating a potential role of sEVs in understanding the therapy's effectiveness.