Mannose Promotes β-Amyloid Pathology by Regulating BACE1 Glycosylation in Alzheimer's Disease.

Hyperglycemia accelerates Alzheimer's disease (AD) progression, yet the role of monosaccharides remains unclear. Here, it is demonstrated that mannose, a hexose, closely correlates with the pathological characteristics of AD, as confirmed by measuring mannose levels in the brains and serum of AD mice, as well as in the serum of AD patients. AD mice are given mannose by intra-cerebroventricular injection (ICV) or in drinking water to investigate the effects of mannose on cognition and AD pathological progression.

Health utility scores of six common cancers in China measured by SF-6Dv2.

Purpose: Given the recent update of SF-6Dv2, detailed data on utility scores for cancer patients by cancer type remain scarce in China and other regions, which limits the precision of cost-utility analyses (CUA) in cancer interventions. The aim of the study was to systematically evaluate utility scores of six common cancers in China measured using SF-6Dv2, and identify the potential factors associated with utility scores.

Methods: A hospital-based cross-sectional survey was conducted from August 2022 to December 2023.

Multi-Omics on Traditional Medicinal Plant of the Genus : Current Progress and Prospect.

stands out among the Ranunculaceae family for its notable use as an ornamental and medicinal plant. Diterpenoid alkaloids (DAs), the characteristic compounds of , have been found to have effective analgesic and anti-inflammatory effects. Despite their medicinal potential, the toxicity of most DAs restricts the direct use of in traditional medicine, necessitating complex processing before use.

Comparative Effects of Different Exercise Types on Cardiovascular Health and Executive Function in Sedentary Young Individuals.

Purpose: The present study aimed to compare the impacts of different exercise types on cardiovascular health and executive function in sedentary young individuals, and to determine the associations between cardiovascular function and executive function (EF) after exercise.

Methods: Sixty-three sedentary participants were randomly divided into high-intensity interval training (HIIT), moderate-intensity continuous training (MICT), resistance exercise (RE), and control groups. Macro- and microvascular endothelial function were assessed using brachial artery flow-mediated dilation and fingertip reactive hyperemia index, respectively.

Intellectual capital, environment-related absorptive capacity and environmental performance: Firm-level evidence from China's E&E sector.

Much of the existing literature on environmental performance has focused on human capital and intangible assets such as environmental policies and strategies, the role of intellectual capital has largely been overlooked. This study aims to investigate the impact of intellectual capital on environmental performance at the firm level, specifically in the electrical and electronics (E&E) sector in China. By considering human, relational, and structural capital as integral elements of intellectual capital, we assess their direct influence on environmental performance and explore how these components interact with other factors in driving environmental outcomes.