Risk of residual/recurrent cervical diseases in HPV-positive women post-conization depends on HPV integration status.

Background: It is crucial to identify post-operative patients with HPV infection who are at high risk for residual/recurrent disease. This study aimed to evaluate the association between HPV integration and clinical outcomes in HPV-positive women after cervical conization, as well as to identify HPV integration breakpoints.

Methods: This retrospective study analyzed data of 791 women who underwent cervical conization for cervical intraepithelial neoplasia grades 2-3 (CIN2-3) between September 2019 and September 2023, sourced from the Fujian and Hubei cervical lesion screening cohorts.

Effect of TKI Maintenance Therapy After Allogeneic Hematopoietic Stem Cell Transplantation on Recurrence of Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia p190 and p210 Transcripts: A Multicentre Study.

Objective: To analyze the impact of tyrosine kinase inhibitor (TKI) maintenance therapy following allogeneic hematopoietic stem cell transplantation (HSCT) in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph + ALL) on recurrence rates and prognosis for the 2 transcripts, p190 and p210.

Methods: We conducted a retrospective analysis of clinical data from 58 patients diagnosed with Ph + ALL who underwent HSCT. All patients received TKI maintenance therapy following hematopoietic reconstruction post-transplantation.

Nomogram vs. Depth of invasion for predicting occult lymph node metastasis in cT1-2N0 buccal squamous cell carcinoma.

Objective: To develop a nomogram prediction model for occult lymph node metastasis (LNM) in patients with cT1-2N0 buccal squamous cell carcinoma (BSCC), then to compare its predictive efficacy against depth of invasion (DOI).

Methods: Clinical data were retrieved for patients undergoing primary tumor resection and neck dissection from June 2020 to August 2024. Based on the risk factors screened by Lasso regression, we established four candidate models: logistic regression, random forest, support vector machine, and XGboost.

Synthesis and characteristics of type 3 resistant waxy corn starch by removal of starch granule surface proteins and heat-moisture treatment.

The type 3 resistant waxy corn starch (RS3) was synthesized by removing starch granule surface proteins and subjecting it to heat-moisture treatment at -20°C, 4°C, and 25°C. Upon applying the dual modification, a significant reduction in particle size and in vitro digestion was observed, while the gelatinization enthalpy, relative crystallinity, and resistant starch content increased. Notably, RS3 treated at 4°C demonstrated the lowest digestion rate of 3.

Design, synthesis and structure-activity relationship of novel 1,2,4-triazolopyrimidin-5-one derivatives targeting GABA and Na1.2 with antiepileptic activity.

A novel class of 7-phenyl-[1,2,4]triazol-5(4H)-one derivatives was designed and synthesized, and their in vivo anticonvulsant activities were evaluated using subcutaneous pentylenetetrazole (Sc-PTZ) and maximal electroshock (MES) tests. Compounds 3u, 4f and 4k exhibited significant anticonvulsant activities in the Sc-PTZ model with ED values of 23.7, 17.