[Clinical characteristics and genetic analysis of maturity-onset diabetes of the young type 2 diagnosed in childhood].

Objectives: To study the clinical manifestations and genetic characteristics of children with maturity-onset diabetes of the young type 2 (MODY2), aiming to enhance the recognition of MODY2 in clinical practice.

Methods: A retrospective analysis was conducted on the clinical data of 13 children diagnosed with MODY2 at the Department of Pediatrics of Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology from August 2017 to July 2023.

Results: All 13 MODY2 children had a positive family history of diabetes and were found to have mild fasting hyperglycemia [(6.

Rationale and design for the thoracic Paravertebral Adjunctive Dexamethasone Palmitate Reducing chronic pain After cardiac surgery (PANDORA) trial: a parallel-group, double-blinded, randomised controlled, single-centre study.

Introduction: Minimally invasive cardiac surgery (MICS) is important for enhanced recovery in cardiac surgery. However, the incidence of chronic postsurgical pain (CPSP) is high and is associated with worsened quality of recovery and life, as well as raised short-term or long-term mortality. The mechanism is not clear, and there is still a lack of safe and effective preventive measures.

NCCN Guidelines® Insights: Lung Cancer Screening, Version 1.2025.

The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Lung Cancer Screening provide criteria for selecting individuals for screening and offer recommendations for evaluating and managing lung nodules detected during initial and subsequent annual screening. These NCCN Guidelines Insights focus on recent updates to the NCCN Guidelines for Lung Cancer Screening.

Lignin-Based Nanoparticles Stabilized Pickering Emulsion for Enhanced Catalytic Hydrogenation.

The development of green and easily regulated amphiphilic particles is crucial for advancing Pickering emulsion catalysis. In this study, lignin particles modified via sulfobutylation were employed as solid emulsifiers to support Pd nanoparticles (NPs), thereby enhancing the catalytic efficiency of biphasic reactions. Sulfobutylation of lignin effectively adjusted the hydrophilic-hydrophobic balance, resulting in controlled emulsion types and droplet sizes.