Early signs of haemorrhages develop in the childhood, nose bleeding being predominant. Recurrent nose bleeding was observed in 130 (89.0%) patients with thrombocytopathies, 37 patients with nasal pathologies, 13 out of 14 children having willebrand's disease, 3 patients suffering from Rendu-Osler disease, in a boy with a factor XIII deficiency, and in a girl with psoriasis.
View Article and Find Full Text PDFThe sensitive orthophenanthroline test was used to reveal paracoagulation in 27 normal newborns, thrombinemia reaching the highest level at the moment of birth and in the period of heavy depression of blood coagulation (on the fifth day of life) was detected. It has been suggested that the physiological role of thrombinemia is in the leveling of hypocoagulation shifts and providing of the local hemostasis. To escape thrombotic complications, drug correction of the hypocoagulation physiological level (activity of prothrombin complex factors is 30-60%) is not recommended.
View Article and Find Full Text PDFCoagulative and thrombocytic hemostasis as well as the fibrinolytic system were studied in 20 patients with chronic glomerulonephritis on plasmapheresis (PA). It is shown that PA promotes activation of platelet aggregation which can be related to their contact activation. Coagulation enhances, antithrombic potential reduces, fibrinogen is mechanically removed as well as fibrin-monomer soluble complexes, fibrin degradation products.
View Article and Find Full Text PDFHemostasis was investigated in 2 groups of patients with systemic scleroderma (SSD) with minimal (12 patients) and moderate (9 patients) activity of the process. It has been shown that in SSD, the triggering factor of intravascular blood coagulation is the release of Willebrand's factor, an activator of platelets, from the impaired endothelium. Hyperaggregation and labilization of platelets characterizes the course of SSD irrespective of the disease activity.
View Article and Find Full Text PDFA system of microtests, adapted for pediatric practice, has been developed, tested, and proposed for practical use. The system includes 13 microtests, 4 of them meet the requirements of a rapid diagnostic test, the others are used as differentiating and specifying. For the first time three levels of the coagulation status have been distinguished in the newborn: physiologic, border and pathologic; this enables orientation in hemorrhagic and thrombohemorrhagic diseases in the newborn.
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