Publications by authors named "L Yvonne Stevenson"
Mercury (Hg) is a potent neurotoxicant and poses a risk to human health through the ingestion of Hg-contaminated fish. Mercury, especially in its organic form methylmercury (MeHg), biomagnifies up food chains such that even small aqueous concentrations of Hg can result in significant concentrations of total Hg in fish. Understanding the ecological and human health risks associated with Hg and MeHg exposure requires an understanding of the factors that affect its bioaccumulation in aquatic species.
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- TTN encodes the protein titin and is commonly associated with rare variants in patients diagnosed with atrial fibrillation (AF) during genetic testing.
- The study compared characteristics and outcomes of patients with AF having pathogenic TTN variants to those without such variants, revealing that TTN(+) patients experience more persistent AF and require more cardioversions.
- Findings indicate that nearly 50% of TTN(+) AF patients develop serious heart issues, emphasizing the importance of specialized evaluation and management for these individuals.
Article Synopsis
- - The DEBIOC trial explored the safety and efficacy of neoadjuvant treatment using oxaliplatin and capecitabine (Xelox) with or without AZD8931 in patients with oesophageal adenocarcinoma, showing moderate safety but limited effectiveness.
- - Researchers analyzed genetic data from 25 pre-treatment and 18 post-treatment biopsy samples to examine how these treatments influenced biological pathways related to cancer through advanced software tools.
- - Their findings identified three molecular subgroups linked to immune response, with treatment affecting immune signaling and tumor-infiltrating lymphocytes, while the addition of AZD8931 promoted a less favorable immunosuppressive environment and common cancer resistance mechanisms.
Between May 2022 and September 2023, the World Health Organization (WHO) Regional Office for Europe engaged in a collaborative effort with affected communities to address the outbreak of mpox in the region. This concerted endeavor led to the development of a risk communication campaign specifically tailored to address the perceptions and needs of the target audience, thereby contributing to the control and the long-term goal of mpox elimination. Various community engagement interventions were implemented, including the establishment of an informal civil society organizations' working group to provide feedback on the WHO mpox campaign, webinars targeting event organizers, and roundtable discussions with country-level responders.
View Article and Find Full Text PDFBackground: Psychosocial evaluations to assess candidacy for advanced heart failure therapies are not standardized across institutions, potentially contributing to disparities in approval for advanced therapies. Remediation rates of psychosocial stressors among patients with advanced HF and reconsideration for advanced therapies have not been well-described.
Methods And Results: We performed a retrospective, single-center study of 647 adults evaluated for heart transplant and ventricular assist device implantation between 2014 and 2020, of whom 89 (14%) were denied for psychosocial stressors, including caregiver, substance use, housing, financial, or mental health concerns.