Publications by authors named "L Yip"
Introduction: The American Association of Endocrine Surgeons drafted Entrustable Professional Activities for Comprehensive Endocrine Surgery to assess trainees in core topics.
Methods: Fourteen Entrustable Professional Activities were defined. There were 10 "core" Entrustable Professional Activities, with 6 having 3 phases (pre-, intra-, and postoperative) and 4 having a single phase.
Reappraisal of BRAFK601E-positive thyroid tumors in the NIFTP era.
Endocr Relat Cancer
December 2024
BRAFK601E is an uncommon mutation typically found in encapsulated follicular-patterned thyroid tumors. Previous studies on BRAFK601E-positive thyroid tumors were conducted before the implementation of the non-invasive follicular neoplasm with papillary-like nuclear features (NIFTP) diagnosis. This study aimed to characterize BRAFK601E-positive tumors and evaluate changes in the diagnosis and management of these patients after the introduction of NIFTP.
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- This study examined how phenylephrine (PE) affects both brain and skeletal muscle microcirculation in rats using a combination of hyperspectral near-infrared spectroscopy and diffuse correlation spectroscopy.
- Results showed that PE caused a decrease in oxygenation and blood flow in skeletal muscle while increasing cerebral oxygenation and perfusion initially, despite a later drop in brain blood flow.
- The findings suggest that while PE induces vasoconstriction in skeletal muscles, it can redirect and enhance blood flow to the brain, indicating a complex interplay between peripheral and cerebral circulation.
Article Synopsis
- The study evaluates how molecular testing can help determine the need for surgery in patients with differentiated thyroid carcinoma (DTC) sizes ranging from 1 to 4 cm and its association with disease recurrence.
- Among the analyzed patients, only 3.8% experienced recurrence, with no significant association found between recurrence and preoperative variables like tumor size, age, or sex.
- Molecular risk groups showed that intermediate risk tumors between 2.1-4 cm had a higher recurrence rate (11.3%) compared to smaller tumors (5.8%), indicating that size and molecular testing are important considerations for treatment decisions.
Article Synopsis
- Kürsteiner canals (KC) are embryological remnants linked to parathyroid and thymic development, with ongoing research aimed at understanding their role in various parathyroid lesions and cysts.
- A study evaluated 62 cystic and 22 non-cystic parathyroid lesions over a 12-year period, identifying distinct KC phenotypes in relation to the presence of parathyroid hormone (PTH).
- The findings reveal that KC commonly appear in parathyroids, particularly in non-PTH cysts, and suggest that these manifestations may originate from KC, while PTH-positive cysts are associated with different characteristics.