Publications by authors named "L Y Y Shin"
Background: Individuals with posttraumatic stress disorder (PTSD) have high rates of cardiovascular disease (CVD) and increased cardiometabolic CVD risk factors (CVDRFs, e.g., hypertension, hyperlipidemia, or diabetes mellitus).
View Article and Find Full Text PDFVascular graft vasospasm is a lethal risk when using grafts for revascularization and reconstructive surgery. Revascularization is a treatment modality for ischemic diseases including Moyamoya disease that requires bypass surgery. Cerebrovascular graft transplantation carries a 5-10% risk of vasospasm, which can lead to devastating neurological sequelae.
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- Prior research was limited in understanding how cardiometabolic risk factors (CVDRFs), like hypertension and diabetes, mediate the link between anxiety/depression and cardiovascular disease (CVD).
- The study followed over 71,000 participants for a decade to assess the impact of anxiety/depression on the development of CVDRFs and the role of neuro-immune mechanisms, with findings showing a clear association and effect differences based on age and sex.
- Results indicated that anxiety/depression significantly increases the risk of developing CVDRFs, especially in younger women, and this relationship may be influenced by neuro-immune pathways.
Controversy exists as to whether anxiety and depression increase deep vein thrombosis (DVT) risk, and the mechanisms mediating potential links remain unknown. We aimed to evaluate the association between anxiety and depression and DVT risk and determine whether upregulated stress-related neural activity (SNA), which promotes chronic inflammation, contributes to this link. Our retrospective study included adults (N = 118 871) enrolled in Mass General Brigham Biobank.
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