Effective Bone Tissue Fabrication Using 3D-Printed Citrate-Based Nanocomposite Scaffolds Laden with BMP9-Stimulated Human Urine Stem Cells.

Effective repair of large bone defects through bone tissue engineering (BTE) remains an unmet clinical challenge. Successful BTE requires optimal and synergistic interactions among biocompatible scaffolds, osteogenic factors, and osteoprogenitors to form a highly vascularized microenvironment for bone regeneration and osseointegration. We sought to develop a highly effective BTE system by using 3D printed citrate-based mPOC/hydroxyapatite (HA) composites laden with BMP9-stimulated human urine stem cells (USCs).

The Softening of Persimmon Fruit Was Inhibited by Gibberellin via DkDELLA1/2.

Texture is an important quality index reflecting a series of sensory evaluations of fruit, and softening is the main texture change of most postharvest fruit. Persimmon fruit () shows a pattern of decreasing firmness after harvest, leading to a short duration of sale and excessive waste. We found that the treatment with gibberellin (GA) could effectively inhibit the postharvest softening of persimmon fruit, but the underlying mechanism is unclear.

Geospatial analysis of sports tourism resources in China's urban clusters: a case study of the Sichuan-Chongqing region utilizing GIS and the geographic detector.

Introduction: This study aims to elucidate the temporal and spatial distribution patterns of sports tourism resources within the Sichuan-Chongqing Urban Agglomeration, examining how these distributions reflect the developmental pathways of urban regions. The theoretical framework posits that the availability and allocation of sports tourism resources are influenced by various geographical and socio-economic factors, with topography, economic conditions, and population density playing pivotal roles in determining their distribution and development.

Methods: Utilizing GeoDetector technology alongside indices such as the Geographic Concentration Index and the Disparities Index, we conducted a comprehensive analysis of the spatiotemporal dynamics of sports tourism resources, revealing that the distribution of these resources serves as a key indicator of urban development speed.

Selective JAK1 inhibitors and the therapeutic applications thereof: a patent review (2016-2023).

Introduction: The family of Janus kinases (JAKs) consists of four intracellular non-receptor tyrosine kinases: JAK1, JAK2, JAK3, and tyrosine kinase 2 (TYK2). Among these four subtypes, JAK1 is the only isoform that can form heterodimers with all three JAKs, and JAK1 dysfunction can lead to inflammation and severe autoimmune diseases. Interest in JAK1 inhibitors has grown tremendously, and the number of inhibitors targeting JAK1 continues to rise annually.

Bacteriophage diversity and novelty revealed by metaviromic analysis of the gut virome in the medicinal Blaps rynchopetera.

The medicinal beetle Blaps rynchopetera is recognized for its antibacterial, anti-inflammatory, and immune-regulating properties. This study utilized metaviromics technology to systematically characterize the viral community within the gut of B. rynchopetera through high-throughput sequencing of gut contents, with a specific focus on the composition of its bacteriophage community.