Publications by authors named "L Y Marlow"
Article Synopsis
- The study explored women's attitudes towards having a choice between HPV self-sampling and traditional clinician cervical screening after they participated in both methods.
- Most women (85%) expressed a desire for this choice and believed it would enhance their screening experience (72%).
- However, some concerns were noted as 23% felt choosing would be challenging, 15% worried about making a decision, and nearly half preferred medical recommendations rather than making a choice themselves, especially among those with lower education levels.
Background: Trials assessing the clinical utility of blood-based multi-cancer early detection (MCED) tests are underway. Understanding public attitudes towards MCED screening is essential if these tests are to be used. We aimed to quantify MCED screening intention and potential barriers and facilitators to uptake.
View Article and Find Full Text PDFBackground: We assessed experiences of human papillomavirus (HPV) vaginal self-sampling and future screening preferences in an ethnically and socio-economically diverse group of women overdue for cervical screening.
Setting And Participants: A postal questionnaire was embedded in the YouScreen self-sampling trial in England: 32.5% (2712/8338) of kit completers returned the survey.
Background: Trials are underway to test the clinical utility of multi-cancer early detection (MCED) blood tests for screening asymptomatic individuals. We sought to understand the acceptability of MCED blood test screening and potential barriers and facilitators to participation among the general public.
Methods: We conducted eleven semi-structured online focus groups with 50-77-year-olds (n = 53) in April-November 2022.
Article Synopsis
- Metastatic castration-resistant prostate cancer (mCRPC) is a severe form of cancer that often leads to poor patient outcomes, prompting the need for better treatment options.
- Researchers developed and characterized three new patient-derived tumor xenograft (PDTX) models to explore the effectiveness of combining CDK4/6 inhibitors with AKT inhibitors, using 3D spheroids to study drug resistance patterns.
- Findings indicated that the combination therapy showed promising results in overcoming resistance to single-agent treatments, which supports future clinical trials for mCRPC patients with specific genetic profiles.