Publications by authors named "L Y Lui"
Background: Improving functioning in adults with major depressive disorder (MDD) and bipolar disorder (BD) is a priority therapeutic objective.
Methods: This retrospective post hoc secondary analysis evaluated 108 patients with MDD or BD receiving the antidepressants vortioxetine, ketamine, or infliximab. The analysis aimed to determine if changes in objective or subjective cognitive function mediated the relationship between depression symptom severity and workplace outcomes.
The geroscience hypothesis proposes that underlying biological processes, such as the accumulation of senescent cells, have deleterious effects on multiple tissues and increase the risk of many chronic conditions with aging. Senescent cells produce heterogenous biomarkers, also called senescence-associated secretory phenotype (SASP). Circulating concentrations of senescence biomarkers may reflect an underlying burden of senescent cells in various tissues.
View Article and Find Full Text PDFWe have proposed to the Food and Drug Administration (FDA) that treatment-related increases in total hip bone mineral density (TH BMD) at two years could be a surrogate endpoint for fracture risk reduction in clinical trials. The qualification of a surrogate includes a strong association of the surrogate with the clinical outcome. We compiled a large database of individual patient data (IPD) through the FNIH-ASBMR-SABRE project, and this analysis aimed to assess the relationship between baseline BMD and fracture risk in the placebo groups.
View Article and Find Full Text PDFArticle Synopsis
- The study investigated microbial communities in the continental deep biosphere of Fennoscandian Shield groundwaters, revealing a vast array of uncultured microorganisms, including 1270 newly identified genomes with seven new classes and various other taxonomic ranks.
- Metatranscriptomic analysis showed that 30 out of 112 novel taxa were active in at least one water sample, suggesting these organisms are potentially significant players in the deep biosphere's metabolic processes.
- The metabolic capabilities of these novel taxa include carbon and nitrogen fixation, as well as sulfur and hydrogen oxidation, indicating their important roles in nutrient and energy cycling within this unique ecosystem.
New Challenges: Use and Interpretation of Radius Bone Mineral Density.
J Clin Endocrinol Metab
December 2024
Article Synopsis
- The study investigates the relationship between low bone mineral density (BMD) at the radius and fracture risk, specifically focusing on wrist fractures and overall skeletal fragility.* -
- Findings suggest that radius BMD is a strong predictor for fractures, including hip and wrist, but does not specifically correlate better with wrist fractures compared to other fracture sites. Wrist fractures typically occur in healthier, younger women and indicate a risk for future fractures.* -
- The research emphasizes a need for further studies to explore the clinical significance of isolated osteoporosis at the radius and whether it should influence treatment decisions.*