Publications by authors named "L Y Foo"
Poor understanding of the cellular and molecular basis of clinical and genetic heterogeneity in progressive multiple sclerosis (MS) has hindered the search for new effective therapies. To address this gap, we analyzed 632,000 single-nucleus RNA sequencing profiles from 156 brain tissue samples of MS and control donors to examine inter- and intra-donor heterogeneity. We found distinct cell type-specific gene expression changes between MS gray and white matter, highlighting clear pathology differences.
View Article and Find Full Text PDFObjectives: We investigated the longitudinal association between Serum Urate (SU) level and Acute Myocardial Infarction (AMI), Stroke, End Stage Renal Failure (ESRF) and all-cause mortality.
Design: We conducted a retrospective hospital-based cohort study of individuals with gout managed in specialist outpatient clinics. Cox proportional hazards regression was used to estimate HR and 95% CI, with adjustments for potential confounders.
Article Synopsis
- - This study researched the effects of omega-3 fatty acids and vitamin D3 supplementation on the nutritional status of newly diagnosed breast cancer patients in Gaza, aiming to tackle cancer-related malnutrition.
- - 88 women were randomly divided into four groups: omega-3, vitamin D, a combination of both, and a control group; the supplements were given for nine weeks while various health measures were taken.
- - Results showed that the combined omega-3 and vitamin D group had significant improvements in nutritional scores, body weight, BMI, blood albumin levels, and protein intake when compared to the other groups.
Article Synopsis
- * 88 participants were randomly assigned to four groups: omega-3, vitamin D, a combination of both, and a control group, receiving respective supplementations for 9 weeks.
- * Results showed that the combined omega-3 and vitamin D group significantly improved overall health status, functional scores, and reduced fatigue and inflammatory markers when compared to the other groups.
Article Synopsis
- Interfacial Polyelectrolyte Complexation (IPC) was used to create composite, micro-scale fibers from keratin, specifically chitosan-keratin (CK) and keratin-keratin (KK) fibers, for potential use as medical sutures.
- The mechanical properties showed that CK fibers were stiffer (higher Young's modulus) while KK fibers had better elongation (strain-at-break) due to unique strain-stiffening characteristics.
- In in vivo tests with mice, the keratin fibers caused minimal immune response and degradation over time, especially the KK fibers, suggesting they could be a viable alternative to standard non-absorbable sutures like Dafilon®.