5-Methoxytryptophan Attenuates Oxidative Stress-Induced Downregulation of PINK1 and Mitigates Mitochondrial Damage and Apoptosis in Cardiac Myocytes.

Mitochondrial dysfunction is a hallmark in the pathogenesis of various cardiovascular diseases. 5-Methoxytryptophan (5-MTP), an intrinsic amino acid metabolite, exerts cardioprotective effects potentially through the preservation of mitochondrial integrity. This study investigates the mechanisms and contexts in which 5-MTP positively impacts mitochondrial function using cultured human ventricular cardiomyocytes (HCMs) and HL-1 cardiac cells subjected to oxidative stress (OS).

Ganglion Cyst in Zone 2 of Guyon's Canal Causing Ulnar Neuropathy With Claw Hand Deformity: A Case Report and Literature Review.

Guyon's canal, a fibro-osseous anatomical tunnel, sometimes harbors underlying pathologies such as a ganglion cyst, leading to symptoms including dysesthesia, paresthesia, and motor weakness in the ulnar nerve distribution. Surgical excision is often the recommended approach to restore normal hand function. Ulnar nerve palsy caused by mechanical compression can benefit from surgical decompression; however, a timely diagnosis is often difficult.

Management of gout in primary care of Hong Kong in accordance with international guidelines: any gaps to bridge?

Background: The global prevalence of gout ranges from 1 to 6.8% in different countries, while around 3% in Hong Kong. Sudden elevated serum urate level (SUA) will result in acute arthritis and repeated flare-ups.

'I was there because I needed to be there': A qualitative study of the experience of older adults hospitalised with COVID-19 in Australia.

Objectives: To explore the experiences of older adult patients hospitalised with COVID-19 infection by identifying any issues they encountered, how they were able or unable to adapt, as well as their opinion of such issues.

Methods: A qualitative study was conducted by inviting a purposive sample of older adults from a metropolitan tertiary hospital in Sydney, Australia, to undertake semi-structured telephone interviews. Data was analysed using a thematic approach and adhered to the COREQ guidelines.

Reviewing the Uncommon Extrahepatic Central Nervous System (CNS) Manifestations of Hepatitis C Virus (HCV) Infection: A Case Report.

This case report aims to shed more light on the increasingly described scenario of extrahepatic central nervous system (CNS) manifestations of hepatitis C virus (HCV) infection. We present a possible rare case of acute disseminated encephalomyelitis manifesting as ring-enhancing lesions on magnetic resonance imaging (MRI) of the head study conducted on a gentleman in his 50s who presented to the hospital with neurologic features, with an evident demonstration of HCV ribonucleic acid (RNA) in the patient's cerebrospinal fluid sampled. A closer differential of tumefactive multiple sclerosis due to HCV was considered as well.