Clinical features and prognosis of anti-MDA5-positive dermatomyositis with coexistent anti-aminoacyl-tRNA synthetase antibodies.

Objectives: This study aimed to evaluate the incidence and clinical significance of coexistence of anti-aminoacyl-tRNA synthetase (anti-ARS) antibody in patients with anti-melanoma differentiation-associated gene 5-positive dermatomyositis (anti-MDA5 + DM).

Methods: We assessed a cohort of 246 consecutive patients with anti-MDA5 + DM. Clinical characteristics and survival rates were compared between patients with and without anti-ARS antibodies.

WTAP/IGF2BP3 Mediated m6A Modification of SOD2 mRNA Aggravates the Tumourigenesis of Colorectal Cancer.

Wilms tumor 1-associated protein (WTAP) has been validated to be a crucial regulator in the tumorigenesis and advancement of diverse malignancies. This study intended to probe the impacts of WTAP on colorectal cancer (CRC) progression from the perspective of N6-methyladenosine (m6A) modification. The differential expression patterns of WTAP in clinical CRC samples and cultured cell lines were validated via qRT-PCR and western blot.

Non-governmental organizations' perceptions of challenges and opportunities for participating in the provision of government-purchased community-based psychiatric rehabilitation services in Shanghai, China: a qualitative study.

Background: In recent years, the Chinese government has increased its support for the development of community-based psychiatric rehabilitation (CBPR) services and initiated pilot programs for government purchasing of CBPR services from non-governmental organizations (NGOs) in order to address the inadequacy of the government's own supply capacity of CBPR services. This study investigated how the NGOs in Shanghai perceived the challenges and opportunities for participating in the provision of government-purchased CBPR services.

Methods: A qualitative descriptive approach was employed in this study.

An Ultrastable Integrated Anode with ∼95 wt.% SiO via In Situ Electrode-Scale Conformal Coating.

SiO-based anodes, considered the most promising candidate for high-energy density batteries, have long been bothered by mechanical integrity issues. Research efforts focus on particle modifications, often overlooking the enhancement of interparticle connections, which can reduce the active material content within the electrode. Herein, an integrated electrode with strong covalent bonding at the electrode scale is designed, achieving excellent mechanical stability with ∼95 wt.