Comprehensive plasma metabolomics analysis of berberine treatment in ulcerative colitis rats by LC-MS/MS.

Background: Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) influenced by multiple factors. Berberine, an isoquinoline alkaloid derived from the root and bark of Franch., has shown promise in managing UC, but its underlying mechanisms remain unclear.

[Electronic nose, HS-GC-MS, and relative odor activity value reveal odor differences and material basis of Glycyrrhizae Radix et Rhizoma products processed with different methods].

The Glycyrrhizae Radix et Rhizoma products processed with different methods, including raw materials(S) and products processed with honey according to the method in the Chinese Pharmacopoeia(Z) and Jianchangbang method(M), were analyzed in terms of the odor profile and volatile components by the electronic nose and headspace-gas chromatography-mass spectrometry(HS-GC-MS). The differential components in the three products were screened by chemometrics, on the basis of which the relative odor activity value(ROAV) was adopted to elucidate the odor differences among different products and the material basis of their odors. The results showed that the electronic nose effectively distinguished the products of Glycyrrhizae Radix et Rhizoma processed with different methods.

Forging new pathways: How farmland abandonment affects decision-making of non-grain production - Insight from China's mountainous areas.

The shift in crop growth in rural households towards non-grain crops is a focus of concern in China's grain security. Land allocation decisions by rural households to abandon farmland can affect crop growth decisions. Prior studies on the relationship between farmland abandonment and rural households' crop growing decisions have been insufficient.

Leveraging high-throughput analytics and automation to rapidly develop high-concentration mAb formulations: integrated excipient compatibility and viscosity screening.

Background: Formulation screening is essential to experimentally balance stability and viscosity in high-concentration mAb formulations. We developed a high-throughput approach with automated sample preparation and analytical workflows to enable the integrated assessment of excipient compatibility and viscosity of mAb formulations.

Methods: Ninety-six formulations of a trastuzumab biosimilar were screened by combining 8 types of excipient modifiers with 4 types of buffers across a pH range of 4.