Vitamin E ameliorates blood cholesterol level and alters gut microbiota composition: A randomized controlled trial.

Background And Aims: Antioxidants, including vitamin E (VE) and grape seed extract (GSE), as anti-aging supplementation have been widely used to improve human health. The gut microbiota plays a crucial role in health and affects the treatment effect of various interventions. However, the role of gut microbiota in VE remains unclear.

Ultrafast Exciton Formation in Perovskite Quantum Rods.

Investigating exciton formation in semiconductor materials is essential for efficient light-to-energy conversion applications. Exciton formation has been extensively studied in two-dimensional materials but is rarely observed in single quantum systems. Here, we construct one-dimensional CsPbBr quantum rods (QRs) with two confined dimensions and one unconfined dimension.

Tomato DC1 domain protein SlCHP16 interacts with the 14-3-3 protein TFT12 to regulate flower development.

Flower development is of great significance for plant reproductive growth, but the molecular mechanisms underlying flower development remain to be fully understood. In this study, a tomato (Solanum lycopersicum L.) Divergent C1 (DC1) domain protein SlCHP16 was identified as a negative regulator of flower development.

PAI-1-driven SFRP2 cancer-associated fibroblasts hijack the abscopal effect of radioimmunotherapy.

The abscopal effect of radioimmunotherapy, wherein tumor shrinkage occurs beyond the irradiated field, is therapeutically promising but clinically rare. The mechanisms underlying this effect remain elusive. Here, in vivo genome-wide CRISPR screening identifies SFRP2 as a potential stromal regulator of the abscopal effect.

Bioinformatics analysis, immunogenicity, and therapeutic efficacy evaluation of a novel multi-stage, multi-epitope DNA vaccine for tuberculosis.

Background: The global tuberculosis (TB) epidemic remains severe. We aimed to develop a therapeutic DNA vaccine as an adjunct to TB treatment to improve efficacy.

Methods: The W545 DNA vaccine was constructed using the M.