Discovery of an Orally Bioavailable STING Inhibitor with In Vivo Anti-Inflammatory Activity in Mice with STING-Mediated Inflammation.

The cyclic GMP-AMP synthase (cGAS)-stimulator of the interferon genes (STING) pathway plays a key role in triggering interferon and inflammatory responses against microbial invasion or tumor. However, aberrant activation of the cGAS-STING pathway is associated with a variety of inflammatory and autoimmune diseases, and thus inhibition of STING is regarded as a potential new approach to treating these diseases. Herein, we report a series of novel indolyl-urea derivatives as STING inhibitors.

Imaging-based prediction of early recurrence and neoadjuvant therapy outcomes for resectable beyond Milan HCC.

Purpose: To develop and validate an MRI-based model for predicting postoperative early (≤2 years) recurrence-free survival (RFS) in patients receiving upfront surgical resection (SR) for beyond Milan hepatocellular carcinoma (HCC) and to assess the model's performance in separate patients receiving neoadjuvant therapy for similar-stage tumors.

Method: This single-center retrospective study included consecutive patients with resectable BCLC A/B beyond Milan HCC undergoing upfront SR or neoadjuvant therapy. All images were independently evaluated by three blinded radiologists.

Image reconstruction for compressed ultrafast photography based on manifold learning and the alternating direction method of multipliers.

Compressed ultrafast photography (CUP) is a high-speed imaging technique with a frame rate of up to ten trillion frames per second (fps) and a sequence depth of hundreds of frames. This technique is a powerful tool for investigating ultrafast processes. However, since the reconstruction process is an ill-posed problem, the image reconstruction will be more difficult with the increase of the number of reconstruction frames and the number of pixels of each reconstruction frame.

Erratum to "Sleep Promotion by 3-Hydroxy-4-iminobutyric Acid in Walnut ".

[This corrects the article DOI: 10.34133/research.0216.

Mechanochemical Synthesis of Type III Porous Liquids from Solid Precursors for the Removal and Conversion of Waste CO from CH.

Porous liquids (PLs) have emerged as a promising class of flow porous materials, offering distinctive benefits for sustainable separation processes coupled with catalytic transformations in the chemical industry. Despite their potential, challenges remain in the realms of synthesis complexity, stability, and the strategic engineering of separation and catalytic sites. In this study, a scalable mechanochemical synthetic approach is reported to fabricate Type III PLs from solid precursors with high stability.