Glucocorticoid signaling mediates lymphopoiesis impairment after cardiac arrest in mice.

Cardiac arrest (CA) is a life-threatening condition that requires immediate medical attention. Considerable advances in resuscitation have led to an increasing number of patients who survive the initial arrest event. However, among this growing patient population, morbidity and mortality rates remain strikingly high.

Neutralizing antibody immune correlates in COVAIL trial recipients of an mRNA second COVID-19 vaccine boost.

Neutralizing antibody titer has been a surrogate endpoint for guiding COVID-19 vaccine approval and use, although the pandemic's evolution and the introduction of variant-adapted vaccine boosters raise questions as to this surrogate's contemporary performance. For 985 recipients of an mRNA second bivalent or monovalent booster containing various Spike inserts [Prototype (Ancestral), Beta, Delta, and/or Omicron BA.1 or BA.

On the steroids extracted from soft corals against the NS3/4A protease of hepatitis C virus.

The Hepatitis C virus (HCV) causes a variety of liver diseases, making it a global health issue that affects millions of people in the world. The NS3/4A protease has been considered a common target for anti-HCV treatments using direct-acting antiviral agents and their derivatives. Of the natural products that have been proposed for novel therapeutic product alternatives, the soft coral compounds are found to contain steroids with various bioactive properties for effective HCV treatments.

Knock-in Rabbit Model of Long QT Syndrome Type-2, Epilepsy, and Sudden Death.

Background: Long QT Syndrome Type-2 (LQT2) is due to loss-of-function variants. encodes K 11.1 that forms a delayed-rectifier potassium channel in the brain and heart.

Study of Sustainability and Health-Related Living Environment Factors Under the Background of Rural Revitalization in the Towns of Guzhen County.

It is crucial to prioritize research and development as part of rural revitalization efforts to promote balanced economic growth, preserve cultural heritage, and reduce urban migration. This ensures sustainability and encourages equal access to opportunities, resources, and a healthy environment for people in both rural and urban areas. For the first time, this study explores the interplay between sustainability (Factor A) and health-related environment (Factor B) under the background of rural revitalization in the eight towns (Chengguan, Haocheng, Liacheng, Renqiao, Hugou, Xinmaqiao, Liuji, and Wangzhuang) located in Guzhen County, Bengbu City, China.