Publications by authors named "L Wyler"
Article Synopsis
- The study investigates the mechanisms behind brain metastasis in renal cell cancer (RCC), linking chemokine expression to increased brain metastasis risk.
- Evidence shows that 15% of RCC patients had brain metastases at autopsy, with high expression of CXCR4 and increased CCR2 and CCL7 in brain lesions compared to primary tumors.
- Findings suggest that CCR2 mediates monocyte recruitment, playing a significant role in the development of brain metastases in RCC patients.
Skin lesions, malaise, and heart failure in a renal transplant recipient.
Transpl Infect Dis
August 2012
A male Caucasian patient developed nodular erythematous skin lesions, malaise, and clinical signs of progressive heart failure 4 months after renal transplantation. Bronchoscopy with bronchoalveolar lavage performed for a small infiltrate seen on a computed tomography scan revealed Trypanosoma, which had at this point not been suspected as a cause. Parasitemia was present, and reactivation rather than transmission of Chagas' disease was established by performing polymerase chain reaction and serology in the donor and recipient.
View Article and Find Full Text PDF