Future investigative directions for novel therapeutic targets in head and neck cancer.

Areas Covered: Here we describe novel agents, their mechanism(s) of action, preclinical results, and ongoing clinical trials in HNSCC.

Expert Opinion: Established therapeutic targets in HNSCC include EGFR (cetuximab) and PD-1 (pembrolizumab and nivolumab). Despite the detection of many other possible targets in HNSCC cell lines and patient tumors, no other therapies have successfully advanced to date.

Injury patterns within clusters of seriously injured occupants comparing real-world crashes in the United States and the European Union.

Objective: Crashworthiness assessments in the United States (U.S.) and the European Union (EU) include a large number of safety regulations and consumer testing programs.

Cluster analysis of seriously injured occupants in motor vehicle crashes.

Permanent monitoring of real-world crashes is important to identify injury patterns and injury mechanisms that still occur in the field despite existing regulations and consumer testing programs. This study investigates current injury patterns at the MAIS 3+ level in the accident environment without limiting the impact direction. The approach consisted of applying unsupervised clustering algorithms to NASS-CDS crash data in order to classify seriously injured, belted occupants into clusters based on injured body regions, biomechanical characteristics and crash severity.

Pain Assessment Clinical Practice Improvement: An Educational Approach in the Home Healthcare Setting.

In the 2 decades since The Joint Commission on Accreditation of Healthcare Organizations designated pain as the fifth vital sign, practitioners have become increasingly aware of the numerous challenges associated with the assessment and management of pain in older adults. Comprehensive pain assessment relies not only on the availability of assessment tools, but also on a clinician's knowledge, training, prior experience, and keen awareness of their own implicit bias and how it may influence their assessment and decisions. The purpose of this project was to develop, implement, and evaluate outcomes of a two-part online learning module on home healthcare clinicians' knowledge of pain.

Designing a Program to Serve Older Adult LGBTQ+ Populations in Home Healthcare.

When compared with their heterosexual cisgender (nontransgender) counterparts, LGBTQ+ older adults are more likely to delay or not seek medical care, often due to fear of real or perceived discrimination from healthcare providers. HCR Home care is a home healthcare agency in Upstate New York that has been delivering high-quality in-home healthcare services for over 40 years. We recognized that we had a unique opportunity to address the vulnerabilities of older adults in the LGBTQ+ community and to better meet their health needs as they age in place.