Publications by authors named "L Whitesell"
Naamidine A reveals a promising zinc-binding strategy for topical antifungal therapy.
Antimicrob Agents Chemother
November 2024
Article Synopsis
- - Fungal diseases impact over a billion individuals globally, presenting a significant health challenge.
- - Naamidine A demonstrates the ability to inhibit various fungal pathogens, but its antifungal effect is compromised when excess zinc is added to the growth medium.
- - The compound shows effectiveness against terbinafine-resistant fungi and has been proven effective in treating dermatomycosis in mice, indicating its potential for topical use in therapy.
Heat Shock Factor 1 (HSF1) is best known as the master transcriptional regulator of the heat-shock response (HSR), a conserved adaptive mechanism critical for protein homeostasis (proteostasis). Combining a genome-wide RNAi library with an HSR reporter, we identified Jumonji domain-containing protein 6 (JMJD6) as an essential mediator of HSF1 activity. In follow-up studies, we found that JMJD6 is itself a noncanonical transcriptional target of HSF1 which acts as a critical regulator of proteostasis.
View Article and Find Full Text PDFCandida species are among the most prevalent causes of systemic fungal infections, which account for ∼1.5 million annual fatalities. Here, we build on a compound screen that identified the molecule N-pyrimidinyl-β-thiophenylacrylamide (NP-BTA), which strongly inhibits Candida albicans growth.
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