Publications by authors named "L Weis"
Alpha-synuclein RT-QuIC assay in gastroduodenal and skin biopsies of Parkinson disease patients.
Ann Clin Transl Neurol
December 2024
In this study, we compared the value of pathological alpha-synuclein (αSyn) seed amplification assay (SAA) in gastric and duodenal biopsies with skin biopsies in Parkinson disease (PD) patients with different disease duration. The accuracy of αSyn SAA was 87.7% in skin, 67.
View Article and Find Full Text PDFLiposuction for Superficialization of Deep Hemodialysis Vascular Access: A Novel Application.
Plast Reconstr Surg Glob Open
December 2024
Background: More than 65% of patients with end-stage renal disease (ESRD) use arteriovenous fistulas (AVFs) for hemodialysis. The increasing incidence of comorbid ESRD and obesity (body mass index, >35 kg/m) precludes patients from kidney transplantation, resulting in a need for long-term, durable AVF access. Compared with traditional superficialization techniques for overlying adiposity, liposuction is minimally invasive and well-tolerated, allowing for earlier fistula use with lower complications.
View Article and Find Full Text PDFArticle Synopsis
- Identifying cognitive impairment in Parkinson's disease is complicated due to varied symptoms and incomplete criteria for diagnosis, with existing screening tools (MMSE and MoCA) lacking a unified approach.
- The study analyzed data from 1,780 Parkinson's patients to establish effective cutoffs for MMSE and MoCA scores across different cognitive stages (normal, mild impairment, dementia).
- A new decision tree model was created, suggesting specific MMSE and MoCA scores to accurately diagnose dementia and mild cognitive impairment, improving diagnostic precision and efficiency for clinicians.
Despite the high prevalence of pathogenic variants (PV) carriers in the South and Southeast regions of Brazil, germline genetic testing for hereditary breast cancer (HBC) is not available in the Brazilian public health system, and the prevalence of Li-Fraumeni syndrome (LFS) is not well established in other regions of Brazil. We assessed the occurrence of p.R337H carriers among women treated for breast cancer (BC) between January 2021 and January 2022 at public hospitals of Brasilia, DF, Brazil.
View Article and Find Full Text PDFBackground: Gastrointestinal dysfunction has emerged as a prominent early feature of Parkinson's Disease, shedding new light on the pivotal role of the enteric nervous system in its pathophysiology. However, the role of immune-cell clusters and inflammatory and glial markers in the gut pathogenetic process needs further elucidation.
Objectives: We aimed to study duodenum tissue samples to characterize PD's enteric nervous system pathology further.