Practical implementation of automated insulin delivery systems in 2025: A French position statement update.

The advent of automated insulin delivery (AID) systems in 2020 marked a disruptive event in managing type 1 diabetes, benefiting children and adults alike. By 2024, advances in real-world data and research motivated an update to the French consensus on AID systems to expand accessibility, refine guidelines, and optimize patient follow-up. AID systems have consistently improved glycemic control by reducing HbA1c, increasing time-in-range (TIR), and minimizing hypoglycemia, with significant benefits even for specific populations such as individuals with poor glycemic control, brittle diabetes, children, very young children, pregnant women, those with insulin resistance or gastroparesis, or after bariatric surgery.

Benzimidazole-based mononuclear polypyridyl Cu(II) complexes: DNA binding, cleavage, and antiproliferative studies.

This paper addresses the synthesis, characterization, DNA binding, cleavage, and antiproliferative activity studies of a series of heteroleptic mononuclear copper(II) complexes [Cu(L)(bpy)](ClO), {1}; [Cu(L)(phen)](ClO), {2}; and [Cu(L)(Mephen)](ClO), {3} derived from different polypyridyl ligands, where in the complex architecture, one 2,6-bis(1-methyl-1-benzo[]imidazol-2-yl)pyridine(Mebzimpy) (L) moiety is connected to the central Cu metal in a tridentate fashion and the bidentate co-ligands are 2,2'-bipyridine (bpy), 1,10-phenanthroline (phen) and 2,9-dimethyl-1,10-phenanthroline (Mephen). All the synthesized complexes were characterized using various spectroscopic and analytical methods, along with the single-crystal X-ray diffraction (SCXRD) technique. The complexes crystallize in a penta-coordinated distorted square pyramidal geometry.

Utilization of Gallium-68 Fibroblast Activation Protein Inhibitor Positron Emission Tomography (⁶⁸Ga-FAPI PET) for Head and Neck Malignancies With Neck Imaging Reporting and Data System (Ni-RADS) Correlation.

Background Head and neck cancers (HNCs) encompass a group of malignancies that arise in the mucosal surfaces of the oral cavity, pharynx, larynx, and other related structures. Advances in imaging modalities such as positron emission tomography-computed tomography (PET-CT) and magnetic resonance imaging (MRI) have improved tumor detection and staging, aiding in personalized treatment approaches. PET-CT is used to diagnose and stage various cancers.

Electrospinning: A New Frontier in Peptide Therapeutics.

The nanofiber technology has recently undergone an unprecedented transformation, finding widespread utilities across diverse scientific disciplines. It is noteworthy that electrospinning approaches have emerged as an adaptable and successful approach to generate fibers ranging in rapidly as a class of therapeutic agents with a high level of target specificity. Peptides encounter several challenges as drugs, including swift breakdown by the body, rapid elimination from the bloodstream, inadequate stability, and restricted ability to cross cell membranes.

Discrepancy in efficiency scores due to sampling error in data envelopment analysis methodology: evidence from the banking sector.

Background: Data Envelopment Analysis (DEA) methodology is considered the most suitable approach for relative performance efficiency calculation for banks as it is believed to be superior to traditional ratio-based analysis and other conventional performance evaluations. This study provides statistical evidence on the sampling error that can creep into performance evaluation studies using the DEA methodology. Inferences are drawn based on samples, and various preventive measures must be taken to eliminate or avoid sampling errors and misleading results.