Publications by authors named "L W de Boo"
Background: Same day discharge (SDD) following atrial fibrillation (AF) ablation procedure has emerged as routine practice, and primarily driven by operator discretion. However, the impacts of SDD on clinical outcomes, healthcare system costs, and patient reported outcomes (PROs) have not been systematically studied.
Methods: We retrospectively analyzed patients undergoing routine AF ablation procedures with SDD versus overnight observation (NSDD).
Background: In the absence of prognostic biomarkers, most patients with early-stage triple-negative breast cancer (eTNBC) are treated with combination chemotherapy. The identification of biomarkers to select patients for whom treatment de-escalation or escalation could be considered remains an unmet need. We evaluated the prognostic value of histopathologic traits in a unique cohort of young, (neo)adjuvant chemotherapy-naïve patients with early-stage (stage I or II), node-negative TNBC and long-term follow-up, in relation to stromal tumor-infiltrating lymphocytes (sTILs) for which the prognostic value was recently reported.
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- The study investigates the prognostic significance of BRCA1-related biomarkers in young, node-negative, chemotherapy-naïve triple-negative breast cancer (TNBC) patients, focusing on how these biomarkers influence overall survival outcomes.
- It included 485 Dutch women diagnosed with TNBC under age 40, assessing their BRCA1 status and tumor-infiltrating lymphocytes (sTILs) to determine outcomes over a 15-year period.
- Results showed that patients with pathogenic germline BRCA1 mutations had worse survival rates compared to those without alterations, but higher levels of sTILs significantly improved overall survival, particularly in patients with tumor BRCA1 promoter methylation.
Introduction: A 56-hole porous tip radiofrequency catheter was developed to provide more uniform cooling with less fluid delivery than a prior 6-hole irrigated design. This study aimed to evaluate the impact of contact force (CF) ablation with the porous tip on complications (congestive heart failure [CHF] and non-CHF related), healthcare resource utilization, and procedural efficiency in patients undergoing de novo paroxysmal atrial fibrillation (PAF) ablations in a real-world setting.
Methods: Consecutive de novo PAF ablations were performed between February 2014 and March 2019 by six operators at a single US academic center.
Background: Durable electrical isolation of pulmonary veins (PVs) is associated with better outcomes after atrial fibrillation (AF) ablation, but previous studies of AF recurrence have reported high rates of reconnection despite successful acute isolation. This study aims to quantify historical trends in the durability of PV isolation (PVI) as radiofrequency (RF) ablation catheters, additional ablation technologies, and associated workflows have evolved.
Methods: The study population included adult patients receiving a first repeat ablation for AF between September 2013 and July 2019 at the study site.