Unilateral and bilateral PVP for thoracolumbar OVCF with distant lumbosacral pain: a single-center retrospective analysis.

Backgrounds: Previous studies have found that percutaneous vertebroplasty (PVP) can effectively improve the local pain of the affected vertebra caused by thoracolumbar osteoporotic vertebral compression fracture (OVCF) regardless of unilateral or bilateral puncture, but there are few reports on whether it is equally effective for the accompanying distant lumbosacral pain.

Objective: To analyze the clinical effect of unilateral or bilateral PVP on thoracolumbar OVCF with distant lumbosacral pain.

Methods: The clinical data of patients with single-stage OVCF treated with PVP in our hospital from March 2019 to March 2023 were retrospectively analyzed.

Microplastic Migration and Transformation Pathways and Exposure Health Risks.

Plastics play a crucial role in modern life, but improper use and disposal have resulted in microplastics becoming widespread in the environment, raising significant concerns about both the environment and human health. Extensive research has explored the transformation mechanisms, bioaccumulation, ecological impacts, and health risks associated with microplastics. The present review first analyzes the migration, transformation, and degradation pathways of microplastics on a global scale, and then synthesizes current knowledge on the types, sources, and migration pathways of microplastics in soil, atmosphere, and aquatic environments, emphasizing transformation mechanisms like photo-aging and microbial degradation, and detailing their ecological and human health impacts.

Bimodal In Situ Analyzer for Circular RNA in Extracellular Vesicles Combined with Machine Learning for Accurate Gastric Cancer Detection.

Circular RNAs in extracellular vesicles (EV-circRNAs) are gaining recognition as potential biomarkers for the diagnosis of gastric cancer (GC). Most current research is focused on identifying new biomarkers and their functional significance in disease regulation. However, the practical application of EV-circRNAs in the early diagnosis of GC is yet to be thoroughly explored due to the low accuracy of EV-circRNAs analysis.

Binding-Site Directed Selection and Large-Scale Click-Synthesis of a Coagulation Factor XIa-Inhibiting Circular DNA Aptamer.

Factor XIa (FXIa) is a plasma protease that plays a crucial role in the intrinsic pathway of blood coagulation, making it a promising target for antithrombotic therapy. Circular DNA aptamers, with their dramatically enhanced biological and structural stability, hold great potential as new-generation DNA-based anticoagulants. However, the functional selection and large-scale synthesis of them remains a substantial challenge.