Suhexiang pill for acute ischemic stroke in real-world practice setting (SUNRISE): protocol of a multicenter registry.

Background: Suhexiang (SHX) pill is widely used for treating acute ischemic stroke (AIS). Experimental and randomized controlled trials suggested that SHX pill was beneficial for patients with AIS. However, the effectiveness of SHX pill in real-world practice setting remains unclear.

Optimized Cerium vanadate catalytic host with simple heterostructure engineering achieving regulated polysulfide deposition for high-performance Lithium-Sulfur batteries under harsh conditions.

Meliorating the behavior deposition of lithium polysulfides (LiPS) is crucial for enhancing the electrochemical performance of sulfur cathodes, which could be implemented by the precise modulation on the catalytic host. Herein, heterostructure engineering is employed to tune up the catalytic capability of CeVO, by introducing CeO through a simple adjustment in the addition sequence of reactants. The formed CeVO/CeO heterostructure has been demonstrated to exhibit appropriate interaction strength with LiPS for accelerating the catalytic conversion process, as well as an engineered surface for inducing three dimensional (3D) LiS deposition, thereby endowing the corresponding sulfur cathodes with excellent electrochemical performance under harsh conditions.

Phytic acid-based nanomedicine against mTOR represses lipogenesis and immune response for metabolic dysfunction-associated steatohepatitis therapy.

Metabolic dysfunction-associated steatohepatitis (MASH) is one of the most common chronic liver diseases and is mainly caused by metabolic disorders and systemic inflammatory responses. Recent studies have indicated that the activation of the mammalian (or mechanistic) target of rapamycin (mTOR) signaling participates in MASH progression by facilitating lipogenesis and regulating the immune microenvironment. Although several molecular medicines have been demonstrated to inhibit the phosphorylation or activation of mTOR, their poor specificity and side effects limit their clinical application in MASH treatment.

Osteoporosis under psychological stress: mechanisms and therapeutics.

Psychological stress has been associated with the onset of several diseases, including osteoporosis. However, the underlying pathogenic mechanism remains unknown, and effective therapeutic strategies are still unavailable. Growing evidence suggests that the sympathetic nervous system regulates bone homeostasis and vascular function under psychological stress, as well as the coupling of osteogenesis and angiogenesis in bone development, remodeling, and regeneration.