Publications by authors named "L W Stranahan"
The genetic and molecular determinants that underlie the heterogeneity of (Mtb) infection outcomes in humans are poorly understood. Multiple lines of evidence demonstrate that mitochondrial dysfunction can exacerbate mycobacterial disease severity and mutations in some mitochondrial genes confer susceptibility to mycobacterial infection in humans. Here, we report that mutations in mitochondria DNA (mtDNA) polymerase gamma (POLG) potentiate susceptibility to Mtb infection in mice.
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- A 16-year-old male shih tzu presented with gagging, coughing, lethargy, and difficulty breathing, prompting an emergency visit.
- Thoracic X-rays showed significant lung issues, leading to the diagnosis of acute respiratory distress syndrome (ARDS), but the dog did not improve with oxygen therapy.
- Necropsy revealed a pheochromocytoma, linking it to the ARDS, highlighting that this condition should be considered a risk factor for respiratory distress in dogs.
A 57-y-old male yellow-naped parrot () was presented because of lethargy, inappetence, and weight loss. Hematology and serum biochemistry were unremarkable, and imaging revealed a mass in the distal esophagus at the coelomic inlet. The luminal diameter of the esophagus was reduced in this area, and passage of ingesta was limited.
View Article and Find Full Text PDFIntraneural perineurioma is an exceptionally rare neoplasm in animals. This case study comprises a series of three cases and a brief literature review focusing on canine intraneural perineurioma. The pathological and immunohistochemical findings are documented, revealing that canine intraneural perineurioma frequently affects adult dogs aged between 3 and 10 years old, with a male predominance.
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- Achieving successful surgeries in orthopedic patients with metabolic diseases like diabetes is difficult due to high levels of reactive oxygen species (ROS) that impair bone healing.* -
- The study introduces thiol-methacrylate scaffolds designed to absorb excess ROS while allowing for custom mechanical properties, achieving a high porosity of 97.0% with effective pore sizes.* -
- In diabetic rat models, these scaffolds led to a 66% increase in new bone volume and showed promising results in promoting bone growth and vascularization without causing toxicity.*