Outpatient Opioid Monitoring and Reclamation Following Minimally Invasive Repair of Pectus Excavatum.

Introduction: To decrease diversion of unused opioids following the minimally invasive repair of pectus excavatum (MIRPE), we developed an opioid education monitoring and reclamation program. The aim was to evaluate outpatient opioid use and disposal following MIRPE.

Materials And Methods: A retrospective review was conducted at a single center among patients <19 ys who underwent MIRPE with intercostal nerve cryoablation.

Cardiopulmonary Impact of the Minimally Invasive Repair of Pectus Excavatum in Pediatric patients: A Prospective Pilot Study.

Introduction: The physiologic benefits of the minimally invasive repair of pectus excavatum (MIRPE) on cardiopulmonary function are poorly understood in pediatrics. We sought to examine the effects of MIRPE on exercise response during cardiopulmonary exercise testing (CPET).

Methods: A prospective-pilot study was conduct of patients ≤18 years who presented for pectus bar removal.

Diurnal Modulation of Locus Coeruleus Noradrenergic Neurons in Anesthetized Adult Male Rats.

Unlabelled: The locus coeruleus (LC) is the primary source of noradrenaline (NA) in brain and its activity is essential for learning, memory, stress, arousal, and mood. LC-NA neuron activity varies over the sleep-wake cycle, with higher activity during wakefulness, correlating with increased CSF NA levels. Whether spontaneous and burst firing of LC-NA neurons during active and inactive periods is controlled by mechanisms independent of wakefulness and natural sleep, is currently unknown.

Patent review of novel compounds targeting opioid use disorder (2018-2024).

Introduction: Opioids have served as a cornerstone in pain management for decades. However, the emergence of increasingly potent synthetic analogs brings forth a range of side effects, including respiratory depression, tolerance, dependence, constipation, and, more importantly, the development of severe and debilitating opioid use disorder (OUD). Search for therapeutics to mitigate OUD has been challenging, and this has called for novel approaches that include the design of small molecules targeting neuronal circuits involved in addiction (opioid, dopamine, serotonin, norepinephrine, and glutamate receptors, etc.

Clozapine rechallenge following myocarditis: a systematic review of rechallenge cases.

Introduction And Objectives: Clozapine is the antipsychotic medication with the greatest efficacy in treatment-resistant schizophrenia (TRS). Unfortunately, clozapine is ceased in approximately 0.2% to 8.