MVA-based SARS-CoV-2 vaccine candidates encoding different spike protein conformations induce distinct early transcriptional responses which may impact subsequent adaptive immunity.

Introduction: Vaccine platforms such as viral vectors and mRNA can accelerate vaccine development in response to newly emerging pathogens, as demonstrated during the COVID-19 pandemic. However, the differential effects of platform and antigen insert on vaccine immunogenicity remain incompletely understood. Innate immune responses induced by viral vector vaccines are suggested to have an adjuvant effect for subsequent adaptive immunity.

The International Bathymetric Chart of the Arctic Ocean Version 5.0.

Knowledge about seafloor depth, or bathymetry, is crucial for various marine activities, including scientific research, offshore industry, safety of navigation, and ocean exploration. Mapping the central Arctic Ocean is challenging due to the presence of perennial sea ice, which limits data collection to icebreakers, submarines, and drifting ice stations. The International Bathymetric Chart of the Arctic Ocean (IBCAO) was initiated in 1997 with the goal of updating the Arctic Ocean bathymetric portrayal.

Immunogenicities of vaccines including the immunoglobulin M-degrading enzyme of , rIde , and protective efficacy against serotype 14 in piglets.

() is a major porcine pathogen. Some strains have a substantial zoonotic potential such as serotype () 14 as the second most important in human infections. To this date no licensed vaccine is available in Europe though subunit vaccines and bacterins have been examined by several scientific groups worldwide.

Effect of powder air polishing and ultrasonic scaling on the marginal and internal interface (tooth-veneer) of ceramic veneers: an in vitro study.

Objectives: This study investigated the influence of prophylactic treatments and thermocycling on the marginal and internal veneering interface (tooth-veneer) as well as on the surface texture of ceramic veneers.

Materials And Methods: A total of 32 extracted human premolars were restored with veneers made of lithium disilicate (LDS) or zirconia-reinforced lithium silicate (ZLS). An artificial aging of the specimens was conducted via five cycles of both thermocycling (5/55°C) and prophylactic treatment (powder air polishing or ultrasonic scaling).