Publications by authors named "L W M Van Der Sluis"
Article Synopsis
- CDH1 pathogenic variants are linked to hereditary diffuse gastric cancer (HDGC), increasing the risk of developing diffuse gastric cancer (DGC) and lobular breast cancer (LBC), with prophylactic total gastrectomy being the standard prevention method for at-risk individuals.
- Recent research indicates that the lifetime risk of advanced DGC in CDH1 PV carriers is lower than previously thought, estimated at 13-19%, prompting discussions about the appropriateness of uniform recommendations for prophylactic total gastrectomy given the potential consequences.
- There is a growing interest in utilizing alternative strategies like endoscopic surveillance, focusing on identifying deeper infiltrative lesions rather than all small signet ring cell lesions, to improve individual management of CDH1
A number of species have recently recovered from near-extinction. Although these species have avoided the immediate extinction threat, their long-term viability remains precarious due to the potential genetic consequences of population declines, which are poorly understood on a timescale beyond a few generations. Woolly mammoths (Mammuthus primigenius) became isolated on Wrangel Island around 10,000 years ago and persisted for over 200 generations before becoming extinct around 4,000 years ago.
View Article and Find Full Text PDFCollagen glue has been used for nearly two centuries to consolidate bone material, although its prevalence in museum collections is only now becoming visible. Identifying and removing collagen glue is crucial before the execution of any geochemical or molecular analyses. Palaeolithic bone objects from old excavations intended for radiocarbon dating were first analysed using ZooMS (Zooarchaeology by Mass Spectrometry) to identify the animal species, however peaks characteristic of both cattle and whale were discovered.
View Article and Find Full Text PDFAim: The aim of the study was (a) to develop a three-dimensional numerical model combining the oscillation of a tapered ultrasonic file and the induced irrigant flow along with their two-way interaction in the confinement of a root canal. (b) To validate this model through comparison with experiments and theoretical (analytical) solutions of the flow.
Methodology: Two partial numerical models, one for the oscillation of the ultrasonic file and another one for the irrigant flow inside the root canal around the file, were created and coupled in order to take into account the two-way coupled fluid-structure interaction.