Publications by authors named "L W Guddat"

Encapsulin nanocompartments loaded with dedicated cargo proteins via unique targeting peptides, play a key role in stress resistance, iron storage and natural product biosynthesis. Mmp1 and cysteine desulfurase (Enc-CD) have been identified as the most abundant representatives of family 2 encapsulin systems. However, the molecular assembly, catalytic mechanism, and physiological functions of the Mmp1 encapsulin system have not been studied in detail.

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Weed management is an essential intervention for maintaining food security and protecting biodiversity but is heavily reliant on chemical control measures (, herbicides). Concerningly, only one herbicide has been developed with a new mode of action (MOA) since the 1980s. Therefore, alternative strategies for preventing weed growth need to be explored.

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In the face of increasing resistance to the currently used commercial herbicides and the lack of success in identifying new herbicide targets, alternative herbicides need to be developed to control unwanted monocotyledon grasses in food crops. Here, a panel of 29 novel sulfonylurea-based compounds with fluoroalkoxy substitutions at the phenyl ring were designed and synthesized. Pot assays demonstrated that two of these compounds, and , have strong herbicidal activities against , , , and Steudel at a dosage of 15 g ha.

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Article Synopsis
  • Triasulfuron is a sulfonylurea herbicide that inhibits the enzyme AHAS, important for amino acid synthesis.
  • The study analyzed the crystal structures of AHAS with triasulfuron and two new herbicides, FMO and CMO, revealing different binding interactions.
  • All compounds are strong inhibitors of AHAS, with triasulfuron used at 10-15 g/ha in wheat and FMO/CMO effective at 7.5-30 g/ha against barnyard grass, highlighting the role of accumulative inhibition in herbicide activity.
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Article Synopsis
  • - Chronic hepatitis B virus (HBV) infection is a significant global health issue, leading to high rates of illness and death, even with an available vaccine.
  • - Current treatments only partially clear the virus, requiring patients to manage the infection for life, making the study of HBV's structure and behavior crucial.
  • - Researchers used advanced cryo-electron microscopy to analyze the HBV surface antigen (HBsAg) at near-atomic resolution, revealing how HBsAg forms complex structures that contribute to viral assembly and function.
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