Publications by authors named "L W Boyce-van der Wal"
Article Synopsis
- - Studies have found links between gut microbes and health issues, specifically highlighting that a certain microbial genus (let’s call it “X”) is negatively associated with inflammatory bowel disease (IBD), yet its protective role and mechanisms in IBD remain unexplored.
- - Researchers showed that colonizing mice deficient in “X” with a specific strain (DSM 27924) slows colitis development, affecting the host's lipid profile by raising phosphatidic acids and lowering triglycerides without changing gut microbiome diversity during the condition.
- - The study identifies outer membrane vesicles (OMVs) from “X” in the mice's plasma, which contain metabolites that may regulate immune responses, particularly sulfonolipids (SoLs), and
Article Synopsis
- Current methods to predict sudden cardiac death (SCD) in children with hypertrophic cardiomyopathy (HCM) are insufficient, although late gadolinium enhancement (LGE) in CMR imaging has shown a link to SCD in adults.
- This study aimed to assess the significance of LGE in HCM patients under 21 years, utilizing data from various international centers between 2015 and 2022.
- Results indicated that 32.9% of the 700 patients had LGE, and those with LGE were more likely to experience SCD or related events, emphasizing the potential role of LGE in clinical assessments for younger patients with HCM.
Objectives: Deferred consent enables research to be conducted in the ICU when patients are unable to provide consent themselves, and there is insufficient time to obtain consent from surrogates before commencing (trial) treatment. The aim of this study was to evaluate how former ICU patients reflect on their participation in a study with deferred consent and examine whether their opinions are influenced by the quality of life (QoL) following hospital discharge.
Design: Survey study by questionnaire.
Supplemental oxygen is widely administered to ICU patients, but appropriate oxygenation targets remain unclear. This study aimed to determine whether a low-oxygenation strategy would lower 28-day mortality compared with a high-oxygenation strategy. This randomized multicenter trial included mechanically ventilated ICU patients with an expected ventilation duration of at least 24 hours.
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