The effect of long-term -80°C storage of thyroid biospecimens on RNA quality and ensuring fitness for purpose.

Aims: To establish whether RNA degrades in long-term storage at -80°C and whether RNA integrity numbers (RINs) determine 'fitness for purpose' in severely degraded RNA.

Methods: RNA was extracted from 549 thyroid biospecimens stored at -80°C for 0.1-10.

Radiation induced thyroid cancer: fundamental and applied aspects.

Aim: To describe the epidemiology and pathology of thyroid cancer in Ukraine, and to perform the molecular analysis of genetic alterations more frequently found to be associated to papillary carcinomas (PTC) in a selected group of PTC.

Materials And Methods: Relationship between the thyroid cancer incidence and gender, age, and place of residence of subjects aged 0-18 years at the time of the Chernobyl accident (5427 subjects of thyroid cancer, among which 3996 (73.6%) were children aged 0 to 14 years at the time of the accident, and 1431 (26.