Publications by authors named "L Vomacka"
Comparison of F-GE-180 and dynamic F-FET PET in high grade glioma: a double-tracer pilot study.
Eur J Nucl Med Mol Imaging
March 2019
Background: PET represents a valuable tool for glioma imaging. In addition to amino acid tracers such as F-FET, PET targeting the 18-kDa mitochondrial translocator-protein (TSPO) is of high interest for high-grade glioma (HGG) imaging due to its upregulation in HGG cells. F-GE-180, a novel TSPO ligand, has shown a high target-to-background contrast in HGG.
View Article and Find Full Text PDFBackground: Glioma grading with dynamic F-FET PET (0-40 min p.i.) is typically performed by analysing the mean time-activity curve of the entire tumour or a suspicious area within a heterogeneous tumour.
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- The study focuses on improving bone marrow (BM) dosimetry for patients receiving Lu-177 therapies for prostate cancer and neuroendocrine tumors through a hybrid protocol (HP).
- This new method combines multiple abdominal SPECT scans with a single whole-body planar (WB-P) imaging session, aiming to provide accurate dosimetry while being more efficient and patient-friendly.
- Results show the HP yields BM absorbed doses that are comparable to the traditional reference protocol (RP), with only slight deviations, demonstrating its effectiveness for both therapy types.
Data in this article show radioligand uptake (to gamma counter and positron-emission-tomography) as well as polymerase chain reaction analyses of 18 kDa translocator protein (TSPO) quantification. We confirmed specificity of [F]GE180 binding of rodent brain and myocardium by blocking experiments with prior application of non-radioactive GE180, using dynamic in vivo positron-emission-tomography and ex vivo gamma counter measurements. Expression of TSPO was compared between rodent brain and myocardium by quantitative polymerase chain reaction.
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