Publications by authors named "L Vinuela"
Article Synopsis
- Vaginitis is a common issue that leads women to seek medical help, and this study compares the effectiveness of a new Vaginal Panel Real-Time PCR kit (qPCR test) to traditional diagnostic methods for detecting bacterial vaginosis, vulvovaginal candidiasis, and trichomoniasis.* -
- The study analyzed 1,011 vaginal swab specimens and found that the qPCR test had high sensitivity and specificity rates—93.1% sensitivity for bacterial vaginosis, 96.0% for Candida, and it detected cases of trichomoniasis not found in traditional microscopy.* -
- Results suggest that the qPCR test provides a reliable and faster method for detecting vaginitis, although
Introduction: Vaccine-induced immunity against COVID-19 generates antibody and lymphocyte responses. However, variability in antibody titers has been observed after vaccination, and the determinants of a better response should be studied. The main objective of this investigation was to analyze the inflammatory biomarker response induced in healthcare workers vaccinated with BNT162b2, and its association with anti-Spike (a SARS-CoV-2 antigen) antibodies measured throughout a 1-year follow-up.
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- * The assay demonstrated high analytical sensitivity at 50 copies/mL for both clades I and II of MPXV, with clinical sensitivity and specificity rates of 99.21% and 96.64%, respectively.
- * This assay streamlines laboratory processes by integrating nucleic acid extraction and PCR analysis and is crucial for distinguishing between MPXV clades, which is vital for safety in handling potentially regulated samples.
Article Synopsis
- The Monkeypox virus (MPXV), previously limited to Africa, experienced a rapid outbreak in 2022 across non-endemic countries, prompting genomic surveillance in southern Spain.
- Whole genome sequencing of 160 MPXV samples was conducted, revealing genomic profiles and tracking relationships to prior outbreak sequences.
- Notably, a mutation linked to potential drug resistance was found in a patient who died, suggesting implications for treatment efficacy, while most samples showed low mutation rates consistent with DNA viruses.
Article Synopsis
- - The study assessed how the V106 polymorphism affects the effectiveness of doravirine, a medication for HIV, finding low prevalence rates of the V106I mutation, particularly higher in subtypes D and F.
- - Different mutations (V106A, V106M, and Y188L) showed varying impacts on doravirine susceptibility, with V106I having a minimal effect in site-directed mutants and most tested clinical isolates remaining susceptible.
- - Although the V106I mutation's prevalence is low, particularly regarding its impact on doravirine resistance in subtype F1, further research is needed to understand the clinical implications.