SIRT1 CONTRIBUTES TO POLARIZATION OF PERIPHERAL BLOOD MONOCYTES BY INCREASING STAT6 EXPRESSION IN YOUNG PEOPLE WITH OVERWEIGHT AND LOW-RISK OBESITY.

Obesity contributes to the formation of low-intensity systemic inflammation with major participation of monocytes/macrophages. Nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase class III SIRT1 regulates the polarization of macrophages, controlling the inhibition of the M1 subpopulation and stimulating the activation of M2 macrophages. The aim of our study was to determine the regulatory role of SIRT1 in M1/M2 polarization of peripheral blood monocytes in young people with overweight and Class I obesity.

RELATIONSHIP OF THE EATING BEHAVIOR FEATURES WITH ANTHROPOMETRIC INDICATORS AND ENERGY VALUE OF THE DIET IN YOUNG PEOPLE WITH NORMAL WEIGHT AND OVERWEIGHT.

Objective: The aim: Was to determine the relationship between the characteristics of eating behavior with anthropometric indicators and the energy value of the diet in young people with normal weight and overweight.

Patients And Methods: Materials and methods: We examined 84 subjects of both sexes aged from 18 to 25 years. We determined their body weight, height.

Procalcitonin in early prediction of acute severe pancreatitis.

Objective: The aim of the study was to analyze the prognostic potential of procalcitonin in acute pancreatitis complicated by ascites-peritonitis.

Patients And Methods: Materials and methods: The study analyzed the results of a comprehensive examination and treatment of 18 patients with acute pancreatitis complicated by enzymatic ascites-peritonitis, including 13 patients who were treated in the surgical department of KP "Poltava Regional Clinical Hospital. MV Sklifosovsky POR ", and 5 patients of other emergency hospitals in Poltava, in the period from 2017 to 2019.

Liraglutide exerts an anti-inflammatory action in obese patients with type 2 diabetes.

Introduction: Liraglutide (L) is the analogue of human glucagon-like peptide 1 which stimulates glucose-dependent insulin secretion and can modify the level of inflammatory biomarkers. L can influence NF-kB inflammatory cascade, but the mechanisms of anti-inflammatory activities of L remain to be determined. In animal models L influenced an activity of Sirtuin 1(SIRT1).

[Iron deficiency reduces systemic inflammation in obese women].

Objective: Introduction: Iron plays an important role in the functioning of immunological monitoring due to its stimulating and differentiating effect on the immune system. Obesity is accompanied by chronic low grade inflammation and may be accompanied by a change in the concentration of iron in the blood serum. The aim of the study was to determine the level of systemic inflammation in iron deficiency anemia in patients with obesity.