Publications by authors named "L Verlinden"
Article Synopsis
- The vitamin D receptor (VDR) is essential for regulating bone health, and its activation typically involves binding to vitamin D and the recruitment of coactivators for gene transcription.
- This study used mice with a deletion of the VDR-AF2 domain to explore how VDR functions without coactivators, revealing that these mutant mice had significant bone issues compared to regular knockout mice.
- Findings indicated that while a rescue diet could improve some bone problems in one group of mutant mice, coactivator-independent VDR functions likely play a more vital role in organs other than bones, affecting overall mineral homeostasis.
Article Synopsis
- * Residents in long-term care often experience poor physical functioning; the study synthesizes various studies to better understand rehabilitation's impact specifically for these individuals.
- * The review included various research studies that met specific criteria and utilized comprehensive methods to gather data, evaluate quality, and analyze results to provide evidence-based recommendations.
We synthesized two new gemini analogues, and , that incorporate a modified longer side chain containing a cyclopropane group. The evaluation of the bioactivities of the two gemini analogues indicated that the 17,20 threo (20) compound, , is the most active one and is as active as 1,25(OH)D. Docking and molecular dynamics (MD) data showed that the compounds bind efficiently to vitamin D receptor (VDR) with to form an energetically more favorable interaction with His397.
View Article and Find Full Text PDFDown syndrome (DS) is characterized by skeletal and brain structural malformations, cognitive impairment, altered hippocampal metabolite concentration and gene expression imbalance. These alterations were usually investigated separately, and the potential rescuing effects of green tea extracts enriched in epigallocatechin-3-gallate (GTE-EGCG) provided disparate results due to different experimental conditions. We overcame these limitations by conducting the first longitudinal controlled experiment evaluating genotype and GTE-EGCG prenatal chronic treatment effects before and after treatment discontinuation.
View Article and Find Full Text PDFIntroduction: Due to the relatively long life span of rodent models, in order to expediate the identification of novel therapeutics of age related diseases, mouse models of accelerated aging have been developed. In this study we examined skeletal changes in the male and female mutant () mice and in male and female chronically aged mice to determine whether the accelerated aging bone phenotype of the mouse reflects changes in skeletal architecture that occur with chronological aging.
Methods: 2, 6 and 20-23 month old C57BL/6 mice were obtained from the National Institute of Aging aged rodent colony and wildtype and mice were generated as previously described by M.