Exploring Benzo[h]chromene Derivatives as Agents against Protozoal and Mycobacterial Infections.

In this study, the efficacy of benzo[h]chromene derivatives as antiprotozoal and antimycobacterial agents was explored. A total of twenty compounds, including benzo[h]chromene alkyl diesters and benzo[h]chromene-triazole derivatives, were synthesized and tested against , , , and strains of and LIID-01. Notably, compounds , , , and exhibited superior activity against , with IC values of 19.

Antimycobacterial Activity of against and Non-Tuberculous Mycobacteria.

Tuberculosis (TB) remains a major health problem worldwide, and the emergence of multi-resistant strains to first-line drugs has become the biggest obstacle to its treatment. On the other hand, the incidence of non-tuberculous mycobacteria (NTM) in humans has increased remarkably in recent years. The search for new and better treatments against mycobacterial infections is a constant at the global level.

Genetic Diversity of Isolates From an Amerindian Population in Chiapas, México.

This is the first report of the genetic diversity of the complex isolates found in a Mexican-Amerindian setting. In this study, we analyzed isolates collected from the Highlands region of Chiapas, Mexico, by using spoligotyping and whole-genome sequencing analyses. Seventy-three isolates were analyzed initially by spoligotyping; no new spoligotypes were identified.

Kerion celsi caused by Trichophyton tonsurans in an adult.

Tinea capitis is an uncommon infection in adults, and predominantly affects women and the elderly with hormonal disorders and immunosuppression. Clinical features are often polymorphic and atypical. A kerion celsi case in an elderly female patient with type 2 diabetes mellitus and menopause is presented.