Publications by authors named "L Ventriglia"
Biological antioxidant potential (BAP) and Reactive Oxygen Metabolites (dROMs) are two tests complementarily assessing systemic oxidative statuses (SOSs) that are never applied in chronic liver disorders (CLDs). We enrolled 41 ursodeoxycholic acid (UDCA)-naïve Primary Biliary Cholangitis (PBC) patients [age: 58.61 ± 11.
View Article and Find Full Text PDFIntroduction: Trained Immunity represents a novel revolutionary concept of the immunological response involving innate immune cells. Bisphenol A is a well-known endocrine disrupter, widely disseminated worldwide and accumulated in the human body. Due to the increased interest regarding the effects of plastic-derived compounds on the immune system, our purpose was to explore whether BPA was able to induce trained immunity in human primary monocytes using low environmental concentrations.
View Article and Find Full Text PDFArticle Synopsis
- Hepatocellular carcinoma (HCC) is a rising global health concern, particularly due to its association with Non-alcoholic Fatty Liver Disease (NAFLD), which can lead to HCC even without cirrhosis.
- Understanding the molecular pathways involved in HCC is crucial for developing better prognostic models and targeted therapies, with RNA non-coding transcripts (ncRNAs) playing a significant role in cancer-related processes.
- This review highlights the dysregulation of ncRNAs in HCC, explores their implications for diagnosis and treatment, and examines the interplay between ncRNAs, the immune system, oxidative stress, and gut microbiota in HCC progression.
Background & Aims: Non-alcoholic fatty liver disease is increasingly gaining epidemiological ground in liver diseases. Among the proposed non-pharmacologic interventions, dietary interventions have been widely used. Several patients suffering from it complain of gastrointestinal symptoms unrelated to organic gastrointestinal tract disease.
View Article and Find Full Text PDFIntroduction: Accumulating evidence have shown a significant correlation between urinary volatile organic compounds (VOCs) profile and the manifestation of several physiological and pathological states, including liver diseases. Previous studies have investigated the urinary metabolic signature as a non-invasive tool for the early discrimination between non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH), which nowadays represents one of the most important challenges in this context, feasible only by carrying out liver biopsy.
Objectives: The aim of the study was to investigate the differences in the urinary VOCs profiles of non-alcoholic fatty liver disease (NAFLD) patients, diabetes mellitus (T2DM) subjects and NAFLD/T2DM patients.