Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals.

Black individuals experience worse survival after a diagnosis of high-grade serous ovarian carcinoma (HGSC) than White individuals and are underrepresented in ovarian cancer research. To date, the understanding of the molecular and genomic heterogeneity of HGSC is based primarily on the evaluation of tumors from White individuals. In the present study, we performed whole exome sequencing on HGSC samples from 211 Black patients to identify significantly mutated genes and characterize mutational signatures, assessing their distributions by gene expression subtypes.

Homologous recombination deficiency in ovarian high-grade serous carcinoma by self-reported race.

Background: Approximately half of ovarian high-grade serous carcinomas (HGSC) have homologous recombination deficiency (HRD). However, HRD is not well-characterized in Black individuals.

Objective: To characterize HGSC HRD by self-reported race and evaluate whether differences in HRD are associated with ovarian cancer mortality.

BCL6 (B-cell lymphoma 6) expression in adenomyosis, leiomyomas and normal myometrium.

Adenomyosis and leiomyomas are common benign uterine disorders characterized by abnormal cellular proliferation. The BCL6 protein, a transcriptional repressor implicated in cell proliferation and oncogenesis, has been linked to the pathogenesis of endometriosis. This study investigates BCL6 expression in adenomyosis, leiomyomas, and normal myometrium using immunohistochemistry and deep learning neural networks.

Depression in children with abdominal pain in the emergency department.

Objective: This cross-sectional study examined depression and associated impairment in youth presenting to a pediatric emergency department (PED) with abdominal pain.

Methods: Participants were 11-17 years old, presenting to a PED with idiopathic abdominal pain. Participants completed demographics, pain, pain-related impairment, and depression surveys.

Description of Timogenes pipanaco sp. nov., (Scorpiones, Bothriuridae) a new salt flat species from north western Argentina.

We describe Timogenes pipanaco sp. nov. (Scorpiones, Bothriuridae) from north western Argentina.