High-dose vitamin D3 in adults with pulmonary tuberculosis: a double-blind randomized controlled trial.

Background: Tuberculosis, including multidrug-resistant tuberculosis (MDR-TB), is a major global health problem. Individuals with tuberculosis disease commonly exhibit vitamin D deficiency, which may adversely affect immunity and the response to therapy.

Objective: We determined whether adjunctive high-dose vitamin D3 supplementation improves outcomes in individuals with pulmonary tuberculosis disease.

[Implication of laparoscopy in diagnostics of genital tb among women through cytohistological testing of bioptic specimen].

Diagnostics of genital TB among women is a serious challenge because of the absence of specific clinical manifestation and difficulty to obtain material for bacteriological verification of the pathogen. All the cases with ascites and masses in pelvic cavity must undergo thorough testing to exclude tuberculosis. The present article describes 14 suspect cases of genital TB, where along with the mandatory clinical diagnostic studies (including PCR of ascites and bacteriological testing for TB, also on carcinoma of CA-125 ovary) they have conducted laparoscopy, with further cytological and bacteriological testing of bioptic sample.

Outcomes among tuberculosis patients with isoniazid resistance in Georgia, 2007-2009.

Background: The optimal management strategy for patients with isoniazid (INH) monoresistant forms of tuberculosis (TB) has been widely debated. The current daily 9-month regimen of rifampin, pyrazinamide and ethambutol was established based largely on trials in settings with low TB rates and low rates of drug resistance.

Objective: To explore the outcomes of patients with INH-monoresistant TB in the country of Georgia, a setting with both high TB rates and drug-resistant forms of the disease.

Prevalence and risk factors for drug resistance among hospitalized tuberculosis patients in Georgia.

Background: Tuberculosis (TB) control in Georgia follows the World Health Organization-recommended DOTS strategy, and has reached global TB control targets in the treatment of susceptible TB; however, the management of drug-resistant forms of TB still represents a serious problem. A countrywide drug resistance survey (DRS) found that the prevalence of multidrug-resistant TB (MDR-TB) was respectively 6.8% and 27.

[For periodization of history of fight against TB in Georgia].

Evolution of TB programs indicates the importance of analysis of existing experience and reasons of failure in planning of TB strategy for future. In spite of existing scientific researches in the field of history of fight against TB in Georgia, it turned out that the question is not mastered perfectly, various periods are not sorted out and the comparative analysis is not made. On account of this, a request was raised to elaborate a new periodization.